Fused 7-membered cyclic compound and antipsychotic preparation c

Details Fused 7-membered cyclic compound and antipsychotic preparation c Fused 7-membered cyclic compound and antipsychotic preparation c

1993-05-11

1994-05-17

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424451, 424461, 514211, 514221, 540490, 540511, A61F 1300

Patent

active

053126254

ABSTRACT:
A therapeutically effective antipsychotic preparation comprising a fused cyclic compound for the treatment of diseases involving the serotonergic pathway having the formula (I) or salts thereof: ##STR1## wherein both of A and B are carbonyl groups, or one represents a methylene group and the other a carbonyl group, Z represents a sulfur atom, or a nitrogen atom which may be substituted, or a methylene group, R represents an aromatic or heterocylcic group, which may be substituted, X represents a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.5 lower alkyl group, a C.sub.1 -C.sub.5 lower alkoxy group, a C.sub.7 -C.sub.9 arylalkoxy group, a C.sub.1 -C.sub.5 lower acyloxy group, a C.sub.7 -C.sub.10 arylcarbonyloxy group, a hydroxy group, a nitro group or an ester group, and n is an integer of 2 to 10.

REFERENCES:
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Grant and Hack's Chemical Dictionary, p. 299 (1987).
Abstract of J01249769A (1989).
Drug evaluation 6th edition, pp. 111-130 (1986) (American Medical Association).
Laszlo et al., Chem. Abstracts 111, No. 97194 n (1989).
Bagoline et al., Chem. Abstracts 88, No. 145961 n (1978).
Voronkov et al., Chem. Abstracts 95, No. 168491 w (1989).
Graham, et al., Chem. Abstracts 110, No. 211845 g (1989).

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