Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-01-17
1999-03-30
Grumbling, Matthew V.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142242, 544 10, 544 48, A61K 31535, A61K 3154, C07D49804, C07D51304
Patent
active
058890025
ABSTRACT:
1,2,4-Thiadiazine and 1,4-thiazine derivatives represented by the formula ##STR1## wherein A, B, D, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinologic system.
REFERENCES:
patent: 3775312 (1973-11-01), Anderson et al.
patent: 5459138 (1995-10-01), Pirotte et al.
Berge et al., Journal of Pharmaceutical Sciences, vol. 66, No. 1, pp. 1-19 (Jan. 1977).
Vlahos et al., Metabolism, vol. 40, No. 8, pp. 825-829 (Aug. 1991).
Hamill et al., Pflugers Archiv, vol. 391, pp. 85-100 (1981).
Kotovskaya et al., Plenum Publishing Corporation, vol. 13, No. 4, pp. 54-57 (Apr., 1979).
Bao-Shan Huang et al., "Synthesis And Properties Of The Sulfonyl Analogues Of 4(5)-Aminoimidazole-5(4)-carboxamide, 4(5)-(Formylamino) Imidazole-5(4)-carboxamide, Guanine, and Xanthine", J. Med. Chem., vol. 23, 1980, pp. 575-577.
Bernard Pirotte et al., 3-(Alkylamino)-4H-Pyrido(4,3-e)-1,2,4-thiadiazine 1,1-Dioxides as Powerful Inhibitors Of Insulin Release From Rat Pancreatic B-Cells: A New Class of Potassium Channel Openers, J. Med. Chem., vol. 36, 1993, pp. 3211-3213.
Bernard Pirotte et al., A Pyridothiadiazine (BPDZ 44) As A New And Potent Activator Of ATP-Sensitive K+ Channels, Biochemical Pharmacology, vol. 47, No. 8, 1994, pp. 1381-1386.
William D. Vlahos, "Diabetes Prevention In BB Rats By Inhibition of Endogenous Insulin Secretion", Metabolism, vol. 40, No. 8, 1991, pp. 825-829.
Raffa et al., Farmaco, vol. 29, pp. 411-423 (1974).
Alemzadeh et al., Endocrinology, vol. 133, No. 2, pp. 705-712 (1993).
Hattori et al., The Chemical Society of Japan, vol. 46, No. 6, pp. 1890-1891 (1973).
Stapp, The Journal of Organic Chemistry, vol. 34, No. 4, pp. 1143-1145 (Apr. 1969).
Williams et al., J. Org. Chem., vol. 38, No. 1, pp. 20-26 (1973).
Press et al., Journal of Medicinal Chem., vol. 22, No. 6, pp. 725-731 (1979).
Roma et al., Eur. J. Med., vol. 26, pp. 489-496 (1991).
Barnes et al., J.C.S. Chem. Comm., pp. 776-777 (1973).
Topliss et al., J Org Chem, vol. 28, pp. 2313-2319 (Sep. 1963).
Cronin et al., J Med Chem, vol. 11, pp. 136-139 (1968).
Dillard et al., American Chemical Society, vol. 23, pp. 717-722 (1980).
Huang et al., J Med Chem, vol. 23, pp. 575-577 (1980).
Meyer, Journal of Heterocyclic Chemistry, vol. 6, pp. 407-408 (1969).
Chern et al., J. Heterocyclic Chem., vol. 27, pp. 1909-1915 (Nov.-Dec. 1990).
Stoss et al., Chem. Ber., vol. 109, pp. 2097-2106 (1976).
Taylor et al., Br. J. Pharmacol., vol. 111, pp. 42-48 (1994).
Arkhammar et al., The Journal of Biological Chemistry, vol. 262, No. 12, pp. 5448-5454 (1987).
Bellemin et al., J. Heterocyclic Chem., vol. 21, pp. 1017-1021 (1984).
Tamura et al., Chem. Pharm. Bull., vol. 19, No. 1, pp. 119-123 (1971).
Andersen et al., Chemica Scripta, vol. 29, pp. 45-49 (1989).
Jensen et al., Chemica Scripta, vol. 20, pp. 248-250 (1982).
Kreeze et al., Phosphorus and Sulfur, vol. 29, pp. 41-47 (1986).
Ofitserov et al., Khimiia Geterotsiklicheskikh soedinenii, vol. 8, pp. 1119-1122 (1976).
Hansen Holger Claus
Hansen John Bondo
Nielsen Flemming Elmelund
Tagmose Tina M.o slashed.ller
Gregg Valeta
Grumbling Matthew V.
Novo Nordisk A S
Zelson Steve T.
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