Fusarium sporotrichioides mutant strain capable of producing bot

Details Fusarium sporotrichioides mutant strain capable of producing bot Fusarium sporotrichioides mutant strain capable of producing bot

1988-03-28

1989-11-14

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Fungi

435166, 435171, 435929, C12N 114, C12N 177, C12P 500, C12P 102

Patent

active

048807478

ABSTRACT:
Mutants blocked or altered in the production of the trichothecene mycotoxin T-2 have been selected following UV mutagenesis of Fusarium sporotrichioides NRRL 3299. One mutant, NRRL 18339, accumulates the rare trichothecenes and dideacetylaclonectrin and deacetylcalonectrin. The second mutant, NRRL 18340, accumulates trichodiene, the first intermediate on the trichothecene biosynthetic pathway. These compounds are useful toxins or toxic precursors for the production of or investigation of immunotoxins for cancer therapy.

REFERENCES:
A. E. Desjardins et al., "Ancymidol Blocks Trichothecene Biosynthesis and Leads to Accumulation of Trichodiene in Fusarium sporotrichioides and Gibberella pulicaris," Appl. Enviorn. Microbiol., 53: 1860-1865 (1987).
M. N. Beremand, "Isolation and Characterization of Mutants Blocked in T-2 Toxin Biosynthesis," Appl. Environ. Microbiol., 53: 1855-1859 (1987).
R. Greenhalgh et al., "Production and Characterization of Deoxynivalenol and Other Secondary Metabolites of Fusarium culmorum (CMI 14764, HLX 1503)," J. Agric. Food Chem., 34: 98-102 (1986).
R. Greenhalgh et al., "Minor Metabolites of Fusarium roseum (ATCC 28114)," J. Agric. Food Chem., 32: 1261-1264 (1984).
C. J. Carter and M. Cannon, "Structural Requirements for the Inhibitory Action of 12,13-Epoxytrichothecenes on Protein Synthesis in Eukaryotes," Biochem. J., 166: 399-409 (1977).
S. Nozoe et al., "The Structures of Trichodiol and Trichodiene," Tetrahedron, 28: 5105-5111 (1972).
D. Gardner et al., "Calonectrin and 15-Deacetylcalonectrin, New Trichothecanes from Calonectria nivalis," J. C. S. Perkin I, pp. 2576-2578 (1972).
W. P. O. Marasaas et al., In "Toxigenic Fusarium Species, Identity and Mycotoxicology," pp. 7, 154-155, The Pennsylvania State University Press (1984).
Biotech 86-05721, Greenhalgh et al, J. Agric. Food Chem. (1986), 34, 1, 115-118.
Biotech 84-05100, Mohr et al, Helv. Chim. Acta (1984), 67, 2, 406-412.
Biotech 82-02439, Lee et al, Phytopathology (1984) 72, 972.

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