Furyl-substituted purines and adenosine antagonists

Details Furyl-substituted purines and adenosine antagonists Furyl-substituted purines and adenosine antagonists

1994-01-13

1996-03-19

Gupta, Yogendra N.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514261, 514262, 544264, 544265, 544269, A61K 3152, C07D47334

Patent

active

055004288

ABSTRACT:
Compounds of formula I, and pharmaceutically acceptable salts thereof, ##STR1## in which R1 is hydrogen (1-6C)alkyl or (1-4C)alkanoyl; A is --N.dbd.CQ--O--, N.dbd.CQ--NR.sup.8 --, --N.dbd.CQ--CH.dbd.N--or --N.dbd.CH--CQ.dbd.N--;

REFERENCES:
patent: 2807616 (1957-09-01), Falco et al.
Hassan et al, Carbohydrate Research 34, pp. 203-207, 1974.
H. S. El Khadem and R. Sindric, "Synthesis of a 8-(hydroxyalkyl)adenines*",Carbohydrate Research, May 1974, vol. 34, No. 1, pp. 203-207.
Sato and Saito, "Studies on Pyrazines. 17. [1]. An Efficient Synthesis of Pteridine-6-Carboxylic Acids," J. Heterocyclic Chem., vol. 25, 1988, pp. 1737-1740.
"Furterene," The Merck Index, 11th Ed., published by Merck and Co., Rahway, New Jersey, 1989, p. 675, entry 4224.
Temple et al., "Synthesis of Potential Antimalarial Agents. VII. Azaquinolines. I. The Preparation of Some Pteridines and Pyrido [3,4-b] pyrazines (1)," J. Heterocyclic Chem., vol. 7, Oct. 1970, pp. 1195-1202.

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