Furyl or thienyl carbonyl substituted taxanes and pharmaceutical

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514449, 514471, 544 60, 544147, 544375, 546196, 546207, 548525, 549 60, 549214, 549473, 549510, 549511, A61K 3134, A61K 3138, C07D30514

Patent

active

052832538

ABSTRACT:
Taxane derivatives of the formula ##STR1## wherein R.sub.1 is phenyl or p-nitrophenyl,

REFERENCES:
patent: 4814470 (1989-03-01), Colin et al.
patent: 4857653 (1989-08-01), Colin et al.
patent: 4924011 (1990-05-01), Denis et al.
patent: 4924012 (1990-05-01), Colin et al.
patent: 4942184 (1990-07-01), Haugwitz et al.
patent: 4960790 (1990-10-01), Stella et al.
patent: 5015744 (1991-05-01), Holton
patent: 5059699 (1991-10-01), Kingston et al.
patent: 5136060 (1992-08-01), Holton
patent: 5175315 (1992-12-01), Holton
Denis and Greene, "A Highly Efficient, Practical Approach to Natural Taxol", J. Am. Chem. Soc. (1988), 110, 5917-5919.
Holton et al., "A Synthesis of Taxusin", J. Am. Chem. Soc., (1988), 110, pp. 6558-6560.
Holton, "Synthesis of the Tazane Ring System", J. Am. Chem. Soc., (1984), 106, pp. 5731-5732.
Mukerjee et al., ".beta.-Lactams: Retrospect and Prospect", Tetrahedron vol. 34, Report No. 52, pp. 1731-1767 (1978).
Wani et al., "Plant Antitumor Agents. VI. The Isolation and Structure of Taxol, a Novel Antileukemic and Antitumor Agent from Taxus brevifolia", J. Am. Chem. Soc. 93:9, May 5, 1971, pp. 2325-2327.
Samaranayake et al., "Modified Taxols. 5.1 Reaction of Taxol with Electrophilic Reagents and Preparation of a Rearranged Taxol Derivative with Tubulin Assembly Activity3.", J. Org. Chem. 1991, 56, 5114-5119.
Kaiser et al., "Synthesis of Esters of Acid-Unstable Alcohols by Means of n-butyllithium", J. Org. Chem., 1970, 35, 1198.
Ojima et al, "New and Efficient Approaches to the Semisynthesis of Taxol and its C-13 Side Chain Analogs by means of .beta.-Lactam Synthon Method", Tetrahedron vol. 48, No. 34, pp. 6985-7012, 1992.
Witherup et al., "High Performance Liquid Chromatographic Separation of Taxol and Related Compounds From Taxus breyifolia", Jour. of Liquid Chromatography, 12(11), pp. 2117-2132 (1989).
Bartholomew et al., "A Novel Rearrangement Reaction Conversion of 3-(chloromethyl)azetidin-2-ones to Azetidine-3-carboxylic Acid Esters", Tetrahedron Letters, vol. 32, No. 36, pp. 4795-4798, 1991.
Schultz et al., "Synthesis of New N-radicals of Tetrazan-1-yl", Chem. Abstr., vol., 108, No. 37298C, p. 581, 1988.
H. M. Deutsch et al., "Synthesis of Congeners and Prodrugs. 3. Water-Soluble Prodrugs of Taxol with Potent Antitumour Activity", Journal of Medicinal Chem., vol. 32, No. 4, pp. 788-792, (Apr. 1989).
N. F. Magri et al., "Modified Taxols, 4. Synthesis and Biological Activity of Taxols Modified in the Side Chain", vol. 51, No. 2, pp. 298-306, (1988).
V. Senilh et al., "Hemisynthese de nouveaux analogues du taxol. Etude de leur interaction avec la tubuline", C. R. Acad. Sc. Paris, Serie II, vol. 299, No. 15, pp. 1039-1043, Nov. 21, 1984.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Furyl or thienyl carbonyl substituted taxanes and pharmaceutical does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Furyl or thienyl carbonyl substituted taxanes and pharmaceutical, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Furyl or thienyl carbonyl substituted taxanes and pharmaceutical will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-580039

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.