Furyl containing fatty acids, glycosyl phosphatidylinositol (GPI

Details Furyl containing fatty acids, glycosyl phosphatidylinositol (GPI Furyl containing fatty acids, glycosyl phosphatidylinositol (GPI

1997-12-15

2000-04-11

Carr, Deborah D

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549429, 514461, 514557, 514560, 554221, 554222, C07D30702, C07C 53132, C07C 5726

Patent

active

060489898

ABSTRACT:
A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myristic acid containing various heteroatoms, substituents and unsaturated bonds, including ester-containing analogs, ketocarbonyl-containing analogs, sulfur-containing analogs, double bond- and triple bond-containing analogs, aromatic moiety-containing analogs, nitrated analogs and halogenated analogs.

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