Furyl and thienyl substituted taxanes and pharmaceutical composi

Details Furyl and thienyl substituted taxanes and pharmaceutical composi Furyl and thienyl substituted taxanes and pharmaceutical composi

1992-04-03

1993-07-13

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514449, 514471, 544 59, 544146, 544152, 544379, 546196, 546212, 546214, 548525, 548527, 549 60, 549473, 549510, 549511, A61K 31335, C07D30514

Patent

active

052274004

ABSTRACT:
A taxane derivative of the formula ##STR1## wherein ##STR2## Z is --OT.sub.1, T.sub.1 is hydrogen, hydroxyl protecting group, or --COT.sub.2,

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patent: 4924012 (1990-05-01), Colin et al.
patent: 4942184 (1990-07-01), Haugwitz et al.
patent: 5015744 (1991-05-01), Holton
Denis and Greene, "A Highly Efficient, Practical Approach to Natural Taxol", J. Am. Chem. Soc. 1988, 110, 5917-5919.
Holton et al., "A Synthesis of Taxusin", J. Am. Chem. Soc., 1988, 110, pp. 6558-6560.
Holton, "Synthesis of the Taxane Ring System", J. Am. Chem. Soc., 1984, 106, pp. 5731-5732.
Mukerjee et al., ".beta.-Lactams: Retrospect and Prospect", Tetrahedron vol. 34, Report No. 52, pp. 1731-1767 (1978).
Wani et al., "Plant Antitumor Agents. VI. The Isolation and Structure of Taxol, a Novel Antileukemic and Antitumor Agent from Taxus brevifolia", J. Am. Chem. Soc. 93:9, May 5, 1971, pp. 2325-2327.

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