Furoxan compounds, compositions and methods of use

Details Furoxan compounds, compositions and methods of use Furoxan compounds, compositions and methods of use

2006-11-16

2010-11-23

Chu, Yong (Department: 1626)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C514S248000, C514S364000, C548S125000, C424S718000

Reexamination Certificate

active

07838023

ABSTRACT:
The invention provides novel furoxan compounds, or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one compound, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The compounds and compositions of the invention can also be bound to a matrix. The invention also provides methods for (a) treating cardiovascular diseases; (b) inhibiting platelet aggregation and platelet adhesion caused by the exposure of blood to a medical device; (c) treating pathological conditions resulting from abnormal cell proliferation; (d) treating transplantation rejections, (e) treating autoimmune, inflammatory, proliferative, hyperproliferative or vascular diseases; (f) reducing scar tissue or for inhibiting wound contraction; (g) treating diseases resulting from oxidative stress; (h) treating endothelial dysfunctions; and (j) treating diseases caused by endothelial dysfunctions.

REFERENCES:
patent: 4416893 (1983-11-01), Schonafinger et al.
patent: 4780401 (1988-10-01), Heusser et al.
patent: 4845079 (1989-07-01), Luly et al.
patent: 4885292 (1989-12-01), Ryono et al.
patent: 4894437 (1990-01-01), TenBrink
patent: 4980283 (1990-12-01), Huang et al.
patent: 5034512 (1991-07-01), Hudspeth et al.
patent: 5036053 (1991-07-01), Himmelsbach et al.
patent: 5036054 (1991-07-01), Kaltenbronn et al.
patent: 5055466 (1991-10-01), Weller, III et al.
patent: 5063207 (1991-11-01), Doherty et al.
patent: 5063208 (1991-11-01), Rosenberg et al.
patent: 5064965 (1991-11-01), Ocain et al.
patent: 5066643 (1991-11-01), Abeles et al.
patent: 5071837 (1991-12-01), Doherty et al.
patent: 5075451 (1991-12-01), Ocain et al.
patent: 5089471 (1992-02-01), Hanson et al.
patent: 5095006 (1992-03-01), Bender et al.
patent: 5095119 (1992-03-01), Ocain et al.
patent: 5098924 (1992-03-01), Poss
patent: 5104869 (1992-04-01), Albright et al.
patent: 5106835 (1992-04-01), Albright et al.
patent: 5114937 (1992-05-01), Hamby et al.
patent: 5116835 (1992-05-01), Ruger et al.
patent: 5262165 (1993-11-01), Govil et al.
patent: 5284872 (1994-02-01), Sandrock et al.
patent: 5344991 (1994-09-01), Reitz et al.
patent: 5380738 (1995-01-01), Norman et al.
patent: 5380758 (1995-01-01), Stamler et al.
patent: 5389655 (1995-02-01), Schonafinger et al.
patent: 5393790 (1995-02-01), Reitz et al.
patent: 5409944 (1995-04-01), Black et al.
patent: 5428061 (1995-06-01), Sandrock et al.
patent: 5434178 (1995-07-01), Talley et al.
patent: 5436265 (1995-07-01), Black et al.
patent: 5466823 (1995-11-01), Talley et al.
patent: 5474995 (1995-12-01), Ducharme et al.
patent: 5510368 (1996-04-01), Lau et al.
patent: 5536752 (1996-07-01), Ducharme et al.
patent: 5550142 (1996-08-01), Ducharme et al.
patent: 5552422 (1996-09-01), Gauthier et al.
patent: 5604253 (1997-02-01), Lau et al.
patent: 5604260 (1997-02-01), Guay et al.
patent: 5639780 (1997-06-01), Lau et al.
patent: 5650447 (1997-07-01), Keefer et al.
patent: 5661129 (1997-08-01), Feelisch et al.
patent: 5665077 (1997-09-01), Rosen et al.
patent: 5703073 (1997-12-01), Garvey et al.
patent: 5705583 (1998-01-01), Bowers et al.
patent: 5770645 (1998-06-01), Stamler et al.
patent: 5797887 (1998-08-01), Rosen et al.
patent: 5807847 (1998-09-01), Thatcher et al.
patent: 5824049 (1998-10-01), Ragheb et al.
patent: 5837008 (1998-11-01), Berg et al.
patent: 5874437 (1999-02-01), Garvey et al.
patent: 5883122 (1999-03-01), Thatcher et al.
patent: 5886026 (1999-03-01), Hunter et al.
patent: 5910316 (1999-06-01), Keefer et al.
patent: 5932538 (1999-08-01), Garvey et al.
patent: 5932598 (1999-08-01), Talley et al.
patent: 5948433 (1999-09-01), Burton et al.
patent: 5958926 (1999-09-01), Garvey et al.
patent: 5994294 (1999-11-01), Garvey et al.
patent: 5994444 (1999-11-01), Trescony et al.
patent: 6010715 (2000-01-01), Wick et al.
patent: 6057347 (2000-05-01), Garvey et al.
patent: 6071531 (2000-06-01), Jona et al.
patent: 6087479 (2000-07-01), Stamler et al.
patent: 6133272 (2000-10-01), Garvey et al.
patent: 6153252 (2000-11-01), Hossainy et al.
patent: 6172060 (2001-01-01), Garvey et al.
patent: 6172068 (2001-01-01), Garvey et al.
patent: 6177428 (2001-01-01), Garvey et al.
patent: 6197778 (2001-03-01), Garvey et al.
patent: 6197782 (2001-03-01), Garvey et al.
patent: 6211179 (2001-04-01), Garvey et al.
patent: 6221881 (2001-04-01), Garvey et al.
patent: 6232321 (2001-05-01), Garvey et al.
patent: 6232336 (2001-05-01), Hrabie et al.
patent: RE37234 (2001-06-01), Garvey et al.
patent: 6297260 (2001-10-01), Bandarage et al.
patent: 6316457 (2001-11-01), Garvey et al.
patent: 6331542 (2001-12-01), Carr et al.
patent: 6633272 (2003-10-01), Kumagawa et al.
patent: 0574726 (1993-12-01), None
patent: 0581062 (1994-02-01), None
patent: 0683159 (1995-11-01), None
patent: WO 92/05179 (1992-04-01), None
patent: WO-94/03387 (1994-02-01), None
patent: WO-94/15723 (1994-07-01), None
patent: WO-94/20480 (1994-09-01), None
patent: WO-94/26731 (1994-11-01), None
patent: WO-94/27980 (1994-12-01), None
patent: WO-95/00501 (1995-01-01), None
patent: WO-95/15316 (1995-06-01), None
patent: WO-96/03387 (1996-02-01), None
patent: WO-96/03388 (1996-02-01), None
patent: WO-96/06840 (1996-03-01), None
patent: WO-96/21667 (1996-07-01), None
patent: WO-96/31509 (1996-10-01), None
patent: WO-96/36623 (1996-11-01), None
patent: WO-97/14691 (1997-04-01), None
patent: WO-97/16435 (1997-05-01), None
patent: WO-97/27749 (1997-08-01), None
patent: WO-97/46521 (1997-12-01), None
patent: WO-98/09972 (1998-03-01), None
patent: WO-98/19672 (1998-05-01), None
patent: WO-98/24427 (1998-06-01), None
patent: WO-99/62510 (1999-12-01), None
patent: WO-00/28988 (2000-05-01), None
patent: WO-00/50037 (2000-08-01), None
patent: WO-00/54756 (2000-09-01), None
patent: WO-01/45703 (2001-06-01), None
patent: WO-01/87343 (2001-11-01), None
patent: WO-03/013432 (2003-02-01), None
patent: WO-03/017996 (2003-03-01), None
patent: WO-2005/018561 (2005-03-01), None
patent: WO-2005060603 (2005-07-01), None
Cerecetto et al., Archiv der Pharmazie (Weinheim, Germany), (2000), vol. 333(11), p. 387-393.
PCT International Search Report for Application No. PCT/US06/44680 dated Nov. 6, 2007.
Arzneim. Forsch. Drug Res., 47(II):849-854 (1997).
Biochemical Pharmacol., 43:1281-1288 (1992).
Bioorg & Med. Chem., 8:1727-1732 (2000).
Bioorg & Med. Chem. Letts., 13:4179-4186 (2003).
Br. J. Pharmacol., 114:816-820 (1995).
Brideau, et al., Inflamm Res., 45:68-74 (1996).
Drug Facts and Comparisons, Inc., St. Louis, MO (1993 Ed.).
Farrer, W.V., J. Chem. Soc., 904-906 (1964).
Goodman and Gilman, The Pharmacological Basis of Therapeutics (9th Edition), McGraw-Hill, pp. 617-657 (1995).
Greene and Wuts, Protective Groups in Organic Synthesis, Third Edition, John Wiley & Sons, New York (1999).
Helv. Chim. Acta., 79:1803-1817 (1996).
Ignarro, et al., Proc. Natl. Acad. Sci. USA, 84:9265-9269 (1987).
II Farmaco, 52:339-341 (1997).
II Farmaco, 52:405-510 (1997).
J. Heterocyclic Chem., 10:587-590 (1973).
J. Heterocyclic Chem., 14:1415-1416 (1977).
J. Heterocyclic Chem., 33:327-334 (1996).
J. Med. Chem., 35:3296-3300 (1992).
J. Med. Chem., 37:4412-4416 (1994).
J. Med. Chem., 38:4944-4949 (1995).
J. Med. Chem., 40:463-469 (1997).
J. Med. Chem., 41:5393-5401 (1998).
J. Med. Chem., 42:1422-1427 (1999).
J. Med. Chem., 42:1941-1950 (1999).
J. Med. Chem., 44:3463-3468 (2001).
J. Med. Chem., 46:747-754 (2003) .
J. Med. Chem., 46:3762-3765 (2003).
J. Med. Chem., 47:1840-1846 (2004).
J. Med. Chem., 47:2688-2693 (2004).
Merck Index on CD-ROM, 13th Edition, (2001).
Oae, et al., Org. Prep. Proc. Int., 15(3):165-198 (1983).
Palmer, et al., Nature, 327:524-526 (1987).
Pharmaceutical Research, 14:1750-1758 (1997).
Pharmaceutical Res., 18:157-165 (2001).
Smith and Mar., March's Advanced Organic Chemistry, Reactions, Mechanisms and Structure, Fifth Edition, John Wiley & Sons, Yew York (2001).
Synthetic Comm., 1:121-124 (1971).
Tet. Letts., 36:3337-3340 (1995).
The Physician's Desk Reference (49th Ed.), Medical Economics Company, Inc., Oradel, NJ (1995).
European Application No. 06837911 Supplementary Search Report, date

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