Furopyrimidines and methods of making and using the same derivat

Details Furopyrimidines and methods of making and using the same derivat Furopyrimidines and methods of making and using the same derivat

1998-11-12

2000-08-01

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544280, A61K 31505, C07D48704

Patent

active

060967501

ABSTRACT:
This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in immunocompromised patients. The compounds themselves, methods of making these compounds, and methods of using these compounds are all disclosed. More specifically, furo[2,3-d[pyrimidines are disclosed.

REFERENCES:
patent: 3904624 (1975-09-01), Perronnet et al.
patent: 4996206 (1991-02-01), Taylor et al.
patent: 5028608 (1991-07-01), Taylor et al.
patent: 5248775 (1993-09-01), Taylor et al.
patent: 5254687 (1993-10-01), Taylor et al.
patent: 5344932 (1994-09-01), Taylor
patent: 5346900 (1994-09-01), Gangjee
patent: 5508281 (1996-04-01), Gangjee
Hurlbert et al., "Studies on Condensed Pyrimidine Systems. XXIII. Synthesis of 2,4-Diaminopyrido[2,3-d]pyrimidines from .beta.-Keto Esters", J. Med. Chem., vol. 11, pp. 703-707 (1968).
Hurlbert et al., "Studies on Condensed Pyrimidine Systems. XXIV. The Condensation of 2,4,6-Triaminopyrimidine with Malondialdehyde Derivatives", J. Med. Chem., vol. 11, pp. 708-710 (1968).
Hurlbert et al., "Studies on Condensed Pyrimidine Systems. XXV. 2,4-Diaminopyrido[2,3-d]pyrimidines. Biological Data", J. Med. Chem., vol. 11, pp. 711-717 (1968).
Grivsky et al., "Synthesis and Antitumor Activity of 2,4-Diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine", J. Med. Chem., vol. 23, pp. 327-329 (1980).
Elslager et al., "Folate Antagonists. 20. Synthesis and Antitumor and Antimalarial Properties of Trimetrexate and Related 6-[(phenylamino)methyl]-2,4-quinazolinediamines", J. Med. Chem., vol. 26, pp. 1753-1760 (1983).
Piper et al., "Syntheses and Antifolate Activity of 5-Methyl-5-deaza Analogues of Aminopterin, Methotrexate, Folic Acid, and N.sup.10 -Methylfolic Acid", J. Med. Chem., vol. 29, pp. 1080-1087 (1986).
Werbel et al., "Synthesis and Antimalarial Activity of a Series of 2,4-Diamino-6-[(N-alkylanilino)methyl]quinazolines", J. Heterocyclic Chem., vol. 24, pp. 345-349 (1987).
Gangjee et al., "Classical and Nonclassical Furo[2,3-d]pyrimidines as Novel Antifolates: Synthesis and Biological Activities", J. Med. Chem., vol. 37, No. 8, pp. 1169-1176 (1994).
Gangjee et al., "Novel 2,4-Diamino-5-Substituted-pyrrolo[2,3-d]pyrimidines as Classical and Nonclassical Antifolate Inhibitors of Dihydrofolate Reductases", J. Med. Chem., vol. 38, No. 12, pp. 2158-2165 (1995).
Gangjee et al., "Effect of Bridge Region Variation on Antifolate and Antitumor Activity of Classical 5-Substituted 2,4-Diaminofuro[2,3-d]pyrimidines", J. Med. Chem., vol. 38, No. 19, pp. 3798-3805 (1995).
Gangjee et al., "5-Arylthio-Substituted 2-Amino-4-oxo-6-methylpyrrolo[2,3-d]pyrimidine Antifolates as Thymidylate Synthase Inhibitors and Antitumor Agents", J. Med. Chem., vol. 38, No. 22, pp. 4495-4502 (1995).
Nishimura et al., Chem. Abstracts, C.A. vol. 99:70481a (1983).

Affiliated with

Also associated with

Rating

Furopyrimidines and methods of making and using the same derivat does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Furopyrimidines and methods of making and using the same derivat, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Furopyrimidines and methods of making and using the same derivat will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-664233