Drug – bio-affecting and body treating compositions – Nonspecific immunoeffector – per se ; or nonspecific... – Synthetic or structurally-modified peptidoglycan or...
Patent
1980-08-15
1982-01-26
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Nonspecific immunoeffector, per se ; or nonspecific...
Synthetic or structurally-modified peptidoglycan or...
26034344, 260326D, A61K 3137, C07D49304
Patent
active
043128831
ABSTRACT:
A class of alkyl-substituted angular flurocoumarins, sometimes termed alkylangelicins, useful in the photochemotherapy of psoriasis and in other skin diseases characterized by cellular hyperproliferation or lack of skin pigmentation is disclosed for topical application or systemic administration. Compared with conventional psoralens the described compounds exhibit a lower risk of skin cancer, absence of phototoxicity problems anderithema to the patient so treated. One preferred compound is 5-methylangelicin.
REFERENCES:
Borolin et al., Studies on the photosensitizing properties of Angelicin, an angular furocoumarin forming only monofunctional adducts with the pyrimidine bases of DNA, The Italian Jour. of Biochemistry, p. 258, 1975.
Baccichetti Francarosa
Bordin Franco
Carlassare Francesco
Dall'Acqua Francesco
Guiotto Adriano
Consiglio Nazionale Delle Ricerche
Fan Jane T.
Jiles Henry R.
Weaver D. Paul
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