Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2010-05-04
2011-11-08
Bernhardt, Emily (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S321000
Reexamination Certificate
active
08053437
ABSTRACT:
The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein: R3is tert-butylmethyl, sec-butyl or tert-butyl; X is CH or N; and R4is optionally substituted C1-8alkyl or optionally substituted C3-8cycloalkyl. The invention further relates to pharmaceutical compositions comprising compounds of formula (I), and the use of such compounds in the treatment of a disease selected from osteoporosis, Paget's disease, Chagas's disease, malaria, gingival diseases, hypercalaemia, metabolic bone disease, diseases involving matrix or cartilage degradation, and bone cancer disorders such as bone metastases and associated pain.
REFERENCES:
Biskobing, Expert Opinion on Investigational Drugs, vol. 12, p. 611-621 (2003).
Cai et al. Expert Opinion on Therapeutic Patents, vol. 15, p. 33-48 (2005).
Carrasco et al. Rheumatology Reports, vol. 2, pp. 1-11 (2010).
Quibell Martin
Watts John Paul
Amura Therapeutics Limited
Bernhardt Emily
Edwards Angell Palmer & & Dodge LLP
Williams Kathleen
Yang Weiying
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