Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2009-01-08
2010-12-07
Bernhardt, Emily (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S321000, C544S373000, C546S198000, C435S023000
Reexamination Certificate
active
07846935
ABSTRACT:
The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof,wherein:X is CH or N; andR4is optionally substituted C3-8alkyl or optionally substituted C3-8cycloalkyl.The invention further relates to pharmaceutical compositions comprising compounds of formula (I), and the use of such compounds in the treatment of a disease selected from osteoporosis, Paget's disease, Chagas's disease, malaria, gingival diseases, hypercalaemia, metabolic bone disease, diseases involving matrix or cartilage degradation, and bone cancer disorders such as bone metastases and associated pain.
REFERENCES:
patent: WO-02/057270 (2002-07-01), None
patent: 2005/066180 (2005-07-01), None
Wolff, Manfred E. Burger's Medicinal Chemistry, 5th Ed. Part 1, pp. 975-977 (1995).
Banker et al. “Modern Pharmaceutics”, 3rd Ed. p. 596 (1996).
Martin Quibell, et al.; “Bicyclic peptidomimetic tetrahydrofuro[3,2-b]pyrrol-3-one and hexahydrofuro[3,2-b]pyridine-3-one based scaffolds: synthesis and cysteinyl proteinase inhibition”; Bioorganic & Medicinal Chemistry; 12; (2004; pp. 5689-5710.
Martin Quibel, et al.; “Synthesis and evaluation of cis-hexahydropyrrolo[3-2-b]pyrrol-3-one peptidomimetic inhibitors of CAC1 cysteinyl proteinases”; Bioorganic & Medicinal Chemistry; 12; (2005); pp. 609-625.
Quibell Martin
Watts John Paul
Amura Therapeutics Limited
Bernhardt Emily
Edwards Angell Palmer & & Dodge LLP
Williams Kathleen
Yang Weiying
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