Furans, benzofurans, and thiophenes useful in the treatment of i

Details Furans, benzofurans, and thiophenes useful in the treatment of i Furans, benzofurans, and thiophenes useful in the treatment of i

1999-05-10

2000-08-15

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ortho-hydroxybenzoic acid or derivative doai

514461, 514443, 514465, 514448, 549 6, 549483, 549 62, 549 63, 549488, A61K 3119, A61K 3138, A61K 31335, C07D33304, C07D30702

Patent

active

061037087

ABSTRACT:
This invention provides compounds of Formula I having the structure: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, W, X, Y, and Z are as defined in the specification, or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.

REFERENCES:
patent: 4117151 (1978-09-01), Deschamps et al.
patent: 5596106 (1997-01-01), Cullinan et al.
Caplus DN 125:1412; WO 9602248 Abstract, Fahey Kennan et al., Feb. 1996.
Eckert, T. et al., Arch. Pharm., 315, 1982, pp. 569-570.
Goldenberg, C. et al., Eur. J. Med. Chem., Chim. Ther., 12:1. Jan.-Feb. 1977, pp. 81-86.

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