Furan derivatives as EP 4 receptor antagonists

Details Furan derivatives as EP 4 receptor antagonists Furan derivatives as EP 4 receptor antagonists

2004-10-15

2009-08-04

Shameem, Golam M (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S200000, C549S429000, C549S483000, C549S487000

Reexamination Certificate

active

07569602

ABSTRACT:
A compound of formula (I):or a salt, solvate and chemically protected form thereof, wherein one of R2and R5is:(i) H or an optionally substituted C1-4alkyl group; or(ii) an optionally substituted C5-7aryl; and the other of R2and R5is the other group;m and n can be 0 or 1, and m+n=1 or 2RNis H or optionally substituted C1-4alkylR3is either:(i) carboxy;(ii) a group of formula (II):(iii) a group of formula (III):wherein R is optionally substituted C1-7alkyl, C5-20aryl, or NRN3RN4, where RN3and RN4are independently selected from optionally substituted C1-4alkyl; or(iv) tetrazol-5-yl.

REFERENCES:
patent: 5602136 (1997-02-01), Ruhter et al.
patent: 5607951 (1997-03-01), Macor et al.
patent: 5645566 (1997-07-01), Brenneman et al.
patent: 5663357 (1997-09-01), Teng et al.
patent: 5679692 (1997-10-01), Friary et al.
patent: 5686445 (1997-11-01), Albright et al.
patent: 5834468 (1998-11-01), Breault et al.
patent: 5883106 (1999-03-01), Stevens et al.
patent: 5939436 (1999-08-01), Carling et al.
patent: 5977170 (1999-11-01), Commons et al.
patent: 6008362 (1999-12-01), Commons et al.
patent: 6121671 (2000-09-01), Ko et al.
patent: 6162819 (2000-12-01), Schindler et al.
patent: 6184245 (2001-02-01), Sugawara et al.
patent: 6211197 (2001-04-01), Belley
patent: 6291677 (2001-09-01), Vasudevan et al.
patent: 6380218 (2002-04-01), Moarfat et al.
patent: 6610719 (2003-08-01), Paralkar et al.
patent: 6716864 (2004-04-01), Burk et al.
patent: 6765004 (2004-07-01), Hoekstra
patent: 6797712 (2004-09-01), Maul et al.
patent: 6835212 (2004-12-01), Rozzell et al.
patent: 6849641 (2005-02-01), Tang et al.
patent: 6855706 (2005-02-01), Tanaka et al.
patent: 6861441 (2005-03-01), Clayton et al.
patent: 6878740 (2005-04-01), Sundermann et al.
patent: 6956057 (2005-10-01), Woodward et al.
patent: 7196089 (2007-03-01), Oxford
patent: 7417068 (2008-08-01), Clark
patent: 2002/0040024 (2002-04-01), Apodaca et al.
patent: 2002/0115671 (2002-08-01), Goehring et al.
patent: 2002/0137736 (2002-09-01), Mattes et al.
patent: 2003/0100583 (2003-05-01), Bernardon
patent: 2003/0119817 (2003-06-01), Mehta et al.
patent: 2003/0195190 (2003-10-01), Peschke et al.
patent: 2004/0048889 (2004-03-01), Peters et al.
patent: 2004/0147559 (2004-07-01), Taveras et al.
patent: 2004/0152734 (2004-08-01), Sundermann et al.
patent: 2004/0192758 (2004-09-01), Leban et al.
patent: 2004/0192767 (2004-09-01), Oxford et al.
patent: 2004/0235888 (2004-11-01), Yamamori et al.
patent: 2004/0259880 (2004-12-01), Lockhart et al.
patent: 2005/0004133 (2005-01-01), Makings et al.
patent: 2005/0043386 (2005-02-01), Nishi et al.
patent: 2005/0176987 (2005-08-01), Goossen et al.
patent: 661260 (1995-07-01), None
patent: 776885 (1997-06-01), None
patent: 1108426 (2001-06-01), None
patent: 1 258 473 (2002-11-01), None
patent: 1 258 473 (2002-11-01), None
patent: 03-240066 (1991-10-01), None
patent: 04-253974 (1992-09-01), None
patent: 07-281440 (1995-10-01), None
patent: 09-311401 (1997-12-01), None
patent: 10-287654 (1998-10-01), None
patent: 11-209366 (1999-01-01), None
patent: 2001-139550 (2001-05-01), None
patent: 2004-051628 (2004-02-01), None
patent: 2005-41867 (2005-02-01), None
patent: 2005-046141 (2005-02-01), None
patent: WO9117163 (1991-11-01), None
patent: WO9118897 (1991-12-01), None
patent: WO9221644 (1992-12-01), None
patent: WO9303012 (1993-02-01), None
patent: WO9306118 (1993-04-01), None
patent: WO9402460 (1994-02-01), None
patent: WO9402483 (1994-02-01), None
patent: WO9406796 (1994-03-01), None
patent: WO9521171 (1995-08-01), None
patent: WO9601827 (1996-01-01), None
patent: WO9611911 (1996-04-01), None
patent: WO9807835 (1998-02-01), None
patent: WO9834909 (1998-08-01), None
patent: WO9847894 (1998-10-01), None
patent: WO9851662 (1998-11-01), None
patent: WO9856783 (1998-12-01), None
patent: WO9857925 (1998-12-01), None
patent: WO9857927 (1998-12-01), None
patent: WO9857928 (1998-12-01), None
patent: WO9910322 (1999-03-01), None
patent: WO9919300 (1999-04-01), None
patent: WO/00/06529 (2000-02-01), None
patent: WO 00/18405 (2000-04-01), None
patent: WO/00/18405 (2000-04-01), None
patent: WO/00/24738 (2000-05-01), None
patent: WO/0040561 (2000-07-01), None
patent: WO/0069987 (2000-11-01), None
patent: WO/0157006 (2001-08-01), None
patent: WO/0164676 (2001-09-01), None
patent: WO 01/72302 (2001-10-01), None
patent: WO/0206278 (2002-01-01), None
patent: WO02/18361 (2002-03-01), None
patent: WO02/26727 (2002-04-01), None
patent: WO02/40473 (2002-04-01), None
patent: WO/02058698 (2002-08-01), None
patent: WO/02060898 (2002-08-01), None
patent: WO/02067930 (2002-09-01), None
patent: WO/02067937 (2002-09-01), None
patent: WO02068412 (2002-09-01), None
patent: WO02/083624 (2002-10-01), None
patent: WO03/018585 (2003-03-01), None
patent: WO0/3033503 (2003-04-01), None
patent: WO0/3044015 (2003-05-01), None
patent: WO03/053352 (2003-07-01), None
patent: WO03/055479 (2003-07-01), None
patent: WO03/059871 (2003-07-01), None
patent: WO03/097621 (2003-11-01), None
patent: WO03/097644 (2003-11-01), None
patent: WO03090869 (2003-11-01), None
patent: WO2004/002948 (2004-01-01), None
patent: WO2004/011418 (2004-02-01), None
patent: WO2004/019932 (2004-03-01), None
patent: WO2004/024663 (2004-03-01), None
patent: WO2004024738 (2004-03-01), None
patent: WO2004048349 (2004-06-01), None
patent: WO2004063194 (2004-07-01), None
patent: WO2004069816 (2004-08-01), None
patent: WO2004078169 (2004-09-01), None
patent: WO2004089944 (2004-10-01), None
patent: WO2004094362 (2004-11-01), None
patent: WO2004099199 (2004-11-01), None
patent: WO2005079793 (2005-09-01), None
International Search Report of PCT/GB2004/004392, mailed Jan. 31, 2005.
Lapina et al (2001): STN International HCAPLUS database, Columbus (OH), accession No. 2002: 200984.
Berge et al, Journal of Pharmaceutical Sciences, Jan. 1977, vol. 66, No. 1, pp. 1-1 9.
Lapina et al,,Russian Journal of General Chemistry, 2001, vol. 71, No. 9, pp. 1479-1483.
Hoekstra et al (2000): STN International HCAPLUS database, Columbus (OH), accession No. 2000: 91 1255.
Richard J Davis et al. EP4prostanoid receptor-mediated vasodilatation of human middle cerebral arteries. Br. J. Pharmacol. (2004) 141, 580-585.
Berge, et al., “Pharmaceutically Acceptable Salts”, J. Pharm. Sci., 1977, vol. 66, pp. 1-19.
Arunlakshana, O., et al., “Some quantitative use of drug antagonists”, Brit. J. Pharmacol., 1959, vol. 14, pp. 48-58.
Porretta, G. C., et al., “Research on antibacterial and antifungal agents”, II Farmaco, Ed. Sc., 1987, vol. 42, No. 9, pp. 629-639.
Modrakowski, C., et al., “Synthesis of Pyrene Containing Building Blocks for Dendrimer Synthesis”, Synthesis, 2001, No. 14, pp. 2143-2155.
Wenkert, E., et al., “Polyene Synthesis. Ready Construction of Retinol-Carotene Fragments, (±)-6(E)-LTB3 Leukotrienes, and Corticrocin”, J. Org. Chem., 1990, vol. 55, No. 25, pp. 6203-6214.
Bures, E., “Regioselective Preparation of 2,4-, 3,4,- and 2,3,4-Substituted Furan Rings.”, J. Org. Chem., 1997, vol. 62, No. 25, pp. 8741-8749.
Wang, Y., et al., “A simple synthesis of fluoroalkyl substituted dihydrofurans by rhodium(II)-catalysed 1,3-dipolar reactions”, Tetrahedron, 2001, vol. 57, No. 16, pp. 3383-3387.
Bin, Y., “A Concise Synthesis of the Differentiating Antibiotic L-Azatyrosine”, J. Org. Chem., 1995, vol. 60, No. 8, pp. 2640-2641.
Doll, M. H., et al., “Irreversible Enzyme Inhibitors. Inhibitors of Guinea Pig Complement Derived by Quaternization of Substituted Pyridines with Benzyl Halides”, J. Med. Chem., 1976, vol. 19, No. 9, pp. 1079-1088.
Mndzhoyan, A. L., et al., Doklady Akademii Nauk Armyanskoi SSR, 1957, vol. 25, pp. 277-280.
Valenta, M., et al., “Experiments in the furan series. III. Preparation of some 2,3,5-trisubstituted derivatives”, Collection Czechoslov. Chem. Commun., 1964, vol. 29, pp. 1577-1581.

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