Furan compounds as histamine H 3 modulators

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C544S360000, C544S366000

Reexamination Certificate

active

07429659

ABSTRACT:
Certain furan compounds are histamine H3modulators useful in the treatment of histamine H3receptor mediated diseases.

REFERENCES:
patent: 5217986 (1993-06-01), Pomponi et al.
patent: 5352707 (1994-10-01), Pompni et al.
patent: 5869479 (1999-02-01), Kreutner et al.
patent: 7067507 (2006-06-01), Pulley et al.
patent: 10 017564 (1998-01-01), None
patent: WO 99/12933 (1999-03-01), None
patent: WO 99/12933 (1999-03-01), None
patent: WO 00/53589 (2000-09-01), None
patent: WO 2004/037801 (2004-05-01), None
patent: WO 2004/054973 (2004-07-01), None
patent: WO2005/018557 (2005-03-01), None
Vippagunta et al. Advanced Drug Delivery Reviews, 2001, 48, 3-26.
Giuseppe et al. Expert Opinion on Therapeutic Patents, 1997, 7 (4), 307-323.
Kitbunnadaj et al. Journal of Medicinal Chemistry, 2003, 46, 54455457.
Camfield, C. and Camfield, P. Pediatrics, 2007, 120(1), e52-e55.
Lee and Corren. Expert Opinion on Pharmacotherapy, 2007, 8(5), 701-709.
“Attention Deficit Disorder”, http://www.massgeneral.org/children/adolescenthealth/articles/aa—add.aspx, accessed Sep. 4, 2007.
Lintunen et al. FASEB Journal, 2001.
Brooks et al. Expert Opinion on Investigational Drugs, 2002, 11(12), 1821-27.
Crow, Scott.. Expert Opinion on Investigational Drugs, 1997, 6(4), 427-36.
Langran et al. Emergency Medicine Journal, 2004, 21, 728-741.
Database Biosis “Online” Biosciences Information Service, Philadelphia, PA, US; 1988, Arrang J-M et al: “Phencyclidine Blocks Histamine H-3-Receptors in Rat Brian” (XP002351852). Database accession No. PREV198987074823 abstract & European Journal of Pharmacology, vol. 157, No. 1, 1988, pp. 31-36, ISSN: 0014-2999.
Stark H: “Recent advances in histamine H3/H4 receptor ligands”, Expert Opinion on Therapeutic Patents (Jun. 1, 2003) United Kingdom, vol. 13, No. 6, Jun. 1, 2003, pp. 851-865 (XP002298271), ISSN: 1354-3776, p. 858.
International search report dated Nov. 24, 2005, for corresponding international application PCT/US2005/010632.
Arrang, J.-M. et al. Auto-inhibition of Brain Histamine Release Mediated by a Novel Class (H3) of Histamine Receptor,Nature1983, 302, 832-837.
Ash, A.S.F.; Schild, H.O. Receptors Mediating Some Actions of Histamine.Br. J. Pharmac. Chemother. 1966, 27, 427-439.
Barnes, J.C. et al. The Selective Histamine H3 Receptor Antagonist Thioperamide Improves Cognition and Enhances Hippocampal Acetylcholine Release in Vivo.Soc. Neurosci, Abstr. 1993, 19, 1813.
Black, J.W. et al. Definition and Antagonism of Histamine H2-Receptors.Nature1972, 236, 385-390.
Cardwell, K.S., et al. A New Method for the Formation of 2,4-Disubstituted Oxazoles: Internal Transfer of Oxidation State Through a Molecular Framework,Tetrahedron Lett. 2000, 41(21), 4239-4242.
Ganellin, C.R. et al. Synthesis of Potent Non-Imidazole Histamine H3-Receptor Antagonists:Arch. Pharm. Pharm. Med. Chem. (Weinheim, Ger.) 1998, 331, 395-404.
Ichinose, M.; Barnes, P.J. Histamine H3-Receptors Modulate Nonadrenergic Noncholinergic Neural Bronchoconstriction in Guinea-Pig In Vivo.Eur. J. Pharmacol.1989, 174(1), 49-55.
Imamura, M. et al. Unmasking of Activated Histamine H3-Receptors in Myocardial Ischemia: Their Role as Regulators of Exocytotic Norepinephrine Release.J. Pharmacol. Exp. Ther.1994, 271(3), 1259-1266.
Krause, M. et al. Medicinal Chemistry of Histamine H3Receptor Agonists. InThe Histamine H3Receptor—A Target for New Drugs.Leurs, R.; Timmerman, H., Eds.; Elsevier: 1998; pp. 175-196.
Letavic, M.A. et al. Recent Medicinal Chemistry of the Histamine H3Receptor. Prog. in Med. Chem., in press.
Leurs, R. et al. The Medicinal Chemistry and Therapeutic Potentials of Ligands of the Histamine H3Receptor.Prog. Drug Res. 1995, 45, 107-165.
Lin, J.-S. et al. Involvement of Histaminergic Neurons in Arousal Mechanisms Demonstrated with H3-Receptor Ligands in the Cat.Brain Res. 1990, 523, 325-330.
Linney, I.D. et al. Design, Synthesis, and Structure-Activity Relationships of Novel Non-Imidazole Histamine H3Receptor Antagonists,J. Med. Chem. 2000, 43(12), 2362-2370.
Lovenberg, T.W. et al. Cloning and Functional Expression of the Human Histamine H3Receptor.Mol. Pharmacol. 1999, 55(6), 1101-1107.
Machidori, H. et al. Zucker Obese Rats: Defect in Brain Histamine Control of Feeding.Brain Res. 1992, 590, 180-186.
MacDonald, S.J.F. et al. Discovery of Further Pyrrolidine trans-Lactams as Inhibitors of Human Neutrophil Elastase (HNE) with Potential as Development Candidates and the Crystal Structure of HNE Complexed with an Inhibitor (GW475151).J.Med.Chem. 2002, 45(18), 3878-3890.
Mcleod, R.L. et al. Antimigraine and Sedative Activity of SCH 50971: A Novel Orally-Active Histamine H3Receptor Agonist.Soc. Neurosci. Abstr. 1996, 22, 2010.
Monti, J.M. et al. Effects of Selective Activation or Blockade of the Histamine H3Receptor on Sleep and Wakefulness.Eur. J. Pharmacol. 1991, 205(3), 283-287.
Morisset, S. et al. High Constitutive Activity of Native H3Receptors Regulates Histamine Neurons in Brain.Nature2000, 408, 860-864.
Panula, P. et al. Significant Changes in the Human Brain Histaminergic System in Alzheimer's Disease.Soc. Neurosci. Abstr. 1995, 21, 1977.
Phillips, J.G. and S.M. Ali, Medicinal Chemistry of Histamine H3Receptor Antagonists. InThe Histamine H3Receptor—A Target for New Drugs. Leurs, R.; Timmerman, H., Eds.; Elsevier: 1998; pp. 197-222.
Schlicker, E.; Marr, I. The Moderate Affinity of Clozapine at H3Receptors Is Not Shared by Its Two Major Metabolites and by Structurally Related and Unrelated Atypical Neuroleptics.Naunyn-Schmiedeberg's Arch. Pharmacol. 1996, 353, 290-294.
Stark, H. et al. Developments of Histamine H3-Receptor Antagonists.Drugs Future1996, 21(5), 507-520.
Tozer, M.J.; Kalindjian, S.B. Histamine H3Receptor Antagonists.Exp. Opin. Ther. Patents2000, 10(7), 1045-1055.
Walczynski, K. et al. Non-Imidazole Histamine H3Ligands. Part I. Synthesis of 2-(1)Piperazinyl)- and 2-(Hexahydro-1H-1,4-diazepin-1-yl)benzothiazole Derivatives as H3-Antagonists with H1 Blocking Activities.Farmaco1999, 54, 684-694.
Walczynski, K. et al. Non-Imidazole Histamine H3 Ligands, Part 2: New 2-Substituted Benzothiazoles as Histamine H3 Antagonists. Arch. Pharm. Pharm. Med. Chem. (Weinheim, Ger.) 1999, 332, 389-398.
Yokoyama, H. et al. Effect of Thioperamide, a Histamine H3Receptor Antagonist, on Electrically Induced Convulsions in Mice.Eur. J. Pharmacol. 1993, 234, 129-133.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Furan compounds as histamine H 3 modulators does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Furan compounds as histamine H 3 modulators, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Furan compounds as histamine H 3 modulators will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3982820

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.