Fuopeptide mimetics

Details Fuopeptide mimetics Fuopeptide mimetics

1998-06-01

2000-08-29

Luxton, David

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 291, 530322, 562533, 562570, C07H 1504

Patent

active

061110841

ABSTRACT:
Bioactive fucopeptides and libraries of fucopeptides having advanced activities against P-selectin as sialyl Lewis X mimetics with IC.sub.50 values in the low mM range are synthesized by solid phase synthesis using para-acyloxymethylenzlidene acetal (p-AMBA) as an anchoring group. A rapid parallel synthesis is employed which proceeds with a bi-directional functionalization of glycosylated amino acid derivatives.

REFERENCES:
Wu, Angew. Chem. Int. Ed. Engl 35, 88, 1996.
Lin, J. Am. Chem. Soc. 118, 6826, 1996.

Affiliated with

Also associated with

Rating

Fuopeptide mimetics does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fuopeptide mimetics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fuopeptide mimetics will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1251231