Fungicide compositions

Details Fungicide compositions Fungicide compositions

1988-12-05

1991-01-29

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514388, 514539, A01N 3712, A01N 3744, A01N 4352, A01N 4384

Patent

active

049886932

DESCRIPTION:

BRIEF SUMMARY
FIELD OF INVENTION

The invention relates to synergistic combinations of known fungicidal active ingredients and their application in plant protection.


BACKGROUND OF THE INVENTION

N-alkyl-morpholines are applied as fungicides in plant protection (DE-PS Nos. 1164152 and 1198125 and DD No. 140112).
A disadvantage of the known agents is that they have only a narrow spectrum of activity, preferentially for mildew fungi (Erysiphales) in cereals. By their phytotoxic side effects they can be used only in a restricted field of application.
The various acylamide derivatives (DD Nos. 118 979 and 118 510, DE-PS Nos. 2 515 091, 1 448 810 and 2 903 612, GB-PS No. 1 603 730 and EP No. 26 873), on the other hand, possess a good efficacy against fungi from the group of Oomycetes, but they are inactive against other plant pathogenic fungi of economical importance.
Furthermore, it is known that benzimidazole- and dithiocarbamate fungicides are applied in plant protection to control fungal diseases (GB-PS Nos. 1 193 461, 1 190 614 and 1 000 137). A disadvantage of the benzimidazole fungicides results from the quick appearance of resistance in the target fungus population.
For simultaneous control of different species of fungi the use of a mixture of N-alkyl-morpholines with dithiocarbamates was recommended (DD No. 111 014).
It is also known that N-alkyl-morpholine derivatives in combination with methyl N-(2-methoxyacetyl)-N-(2,6-xylyl)-D,L-alaninate (HU-PS No. T/33363) are beneficially used against fungal disease.


DETAILED DESCRIPTION OF THE INVENTION

The object of the invention is, to enrich the prior art with fungicide compositions of better properties for the practical control of fungal diseases.
The invention is a fungicide composition containing in addition to the conventional carriers and auxiliaries, 5-95 by weight percent of an active ingredient mixture of the following components:
(A) one of the following acylamide derivatives: ne (Cyprofuram); (RE 26745); and
(B) one of the following morpholine derivatives: (Fenpropimorph); N-alkyl(C.sub.12)-2,5-dimethyl morpholine (Aldimorph);
(C) one of the following fungicides
(D) one of the following dithiocarbamate or disulphide derivatives: (Mancozeb); disulphide) (Metiram); ethylenebis(dithiocarbamate)-polyethylenethiuram disulphide] and Propineb [polymeric zinc propylenebis(dithiocarbamate] in a ratio of 1:3 respectively (Polycarbazin)
In the compositions of the invention, the rate of the active ingredients A, B and C is 1:3-5:1-6, advantageously 1:4:4, the rate of the compounds A, B and D is 1:3-5:5-10 advantageously 1:4:10. The compositions according to the invention can be advantageously used to control diseases, which are caused by various species of fungi.
Surprisingly it was found that using the fungicide composition of the invention in the case of numerous species of fungi an increased activity may be observed, which is based on a synergistic rather than an additive action. This can be calculated e.g. according to the Colby's formula; ##EQU1## wherein X is the efficiency of the components A+B and
Another method is the HORSFALL model where the toxic effects of various treatments are compared at the same concentration level, i.e. each component of the fungicide mixture is tested at the total amount of the mixture applied, and the criterion of synergism was as follows: experiment, mixture, partner, if it was used alone at the total amount of the mixture concerned.
If X.sub.i positive, synergism, if X.sub.i negative, antagonism occurred.
In the SUN's model a Comparative Toxicity Index is used, which is calculated as follows: ##EQU2## ED.sub.50 =the efficiency of the known mixture Y, ED.sub.50.sup.B =the efficiency of the active ingredient Z combination.
An additional advantage of the composition of the present invention lies in a reduced risk of formation of resistance, that means in the reduced occurrence of fungal strains resistant to the above mentioned compounds under the selection pressure of the claimed fungicides. This is due to the different mode of action

REFERENCES:
The Pesticide Manual, 8th Ed., Worthing et al, (1987), pp. 49,58,59 and 827.

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