Fungicidal echinocandin derivatives and their preparation

Details Fungicidal echinocandin derivatives and their preparation Fungicidal echinocandin derivatives and their preparation

2005-03-08

2005-03-08

Campbell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S300000, C530S317000, C530S333000, C514S002600, C514S011400

Reexamination Certificate

active

06864233

ABSTRACT:
The invention concerns compounds of general formula (I) wherein: R1represents a hydrogen atom, a hydroxy radical, Ob or Ncd; A represents an oxygen atom, a CH2radical or a NH radical; B represents the radical of a steroid; R3represents a hydrogen atom, a methyl or hydroxyl radical; R4represents a hydrogen atom or a hydroxyl radical; T represents a hydrogen atom, a methyl radical, a CH1CONH2, CH2C≡N radical, a (CH2)2NH2or (CH2)2Nalk+X−radical; X being a halogen atom and alc an alkyl radical; Y represents a hydrogen atom, a hydroxyl radical or a halogen atom or a OSO3H radical; W represents a hydrogen atom or a OH radical; Z represents a hydrogen atom or a methyl radical. The compounds of formula (I) exhibit antifungal properties.

REFERENCES:
patent: 5541160 (1996-07-01), Balkovec et al.
patent: 5202096 (1993-08-01), None
patent: 9527074 (1995-10-01), None
FA Bouffard, et al. Synthesis and antifungal activity of novel cationic pneumocandin B0 derivatives. (1994) Journal of Medicinal Chemistry, 37, 222-225.*
Roy et al, “Mulundocandin . . . Antibiotic”, Journal of Antibiotics, JP, Japan, Antibiotics Research Association, Tokyo, vol. 40, No. 3, Mar. 3, 1987, pp. 275-280.

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