Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2000-02-22
2002-07-09
Robinson, Allen J. (Department: 1616)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S617000
Reexamination Certificate
active
06417216
ABSTRACT:
The present invention relates to novel fungicidal compositions comprising a 2-imidazolin-5-one, which are intended in particular for protecting crops. The invention also relates to a process for protecting crops against fungal diseases.
Compounds derived from 2-imidazolin-5-ones with fungicidal action are known, in particular from European patent application EP 551,048, these compounds making it possible to prevent the growth and development of phytopathogenic fungi which attack or are liable to attack crops.
International patent application WO 96/03044 also discloses a certain number of fungicidal compositions comprising a 2-imidazolin-5-one in combination with one or more fungicidal active materials.
However, it is always desirable to improve the products which can be used by growers in order to combat fungal diseases of crops, and in particular mildews.
It is also always desirable to reduce the doses of chemical products spread into the environment to combat fungal attacks on crops, in particular by reducing the application doses of the products.
It is also always desirable to increase the number of antifungal products available to growers in order that they will find, among these products, the one which is best suited to the grower's specific use.
One aim of the invention is thus to provide a novel fungicidal composition which is useful for the problems outlined above.
Another aim of the invention is to propose a novel fungicidal composition which is useful in the preventive and curative treatment of Solanacea diseases.
Another aim of the invention is to propose a novel fungicidal composition which is of improved efficacy against mildew and/or early blight in Solanaceae.
Another aim of the invention in to propose a novel fungicidal composition which is of improved efficacy against mildew and/or oidium and/or botrytis in grapevine.
It has now been found that these aims may be achieved, partly or totally, by means of the fungicidal compositions according to the present invention.
The subject of the present invention is thus, firstly, fungicidal compositions comprising a compound (I) of formula:
in which:
M represents an oxygen or sulphur atom;
n is an integer equal to 0 or 1;
Y is a fluorine or chlorine atom or a methyl radical;
and a compound (II) which is N-[3′-(1′-chloro-3′-methyl-2′-oxopentan)]-3,5-dichloro4-methylbenzamide;
the compound (I)/compound (II) ratio by weight being from 0.01 to 50, preferably from 0.1 to 10.
The compositions according to the invention are advantageous for combating, in particular, mildews of the Solanaceae, such as potatoes or tomatoes, as well as for combating mildew and oidium of grapevine.
Compound (I) is known, in particular from patent application EP 629,616.
Compound (II) and its use as a fungicide are described in European patent application EP 600,629.
The compound (I)/compound (II) ratio is defined as being the ratio of the weight of these 2 compounds. This is likewise the case for any ratio of 2 chemical compounds, mentioned below in the present text, insofar as a definition different from this ratio is not expressly indicated.
These compositions generally appreciably improve the respective and isolated action of compound (I) and of compound (II) for a number of fungi that are particularly harmful in crops, in particular for Solanaceae, more particularly for mildew of Solanaceae while at the same time retaining an absence of phytotoxicity towards these crops. This therefore results in an improvement in the spectrum of activity and the possibility of decreasing the respective dose of each active material used, the latter quality being particularly advantageous for readily appreciated ecological reasons.
The fungicidal compositions according to the invention for which the compound (I) is the compound of formula (I) in which M is a sulphur atom and n is equal to 0, also known as (4S)4-methyl-2-methylthio-4-phenyl-1-phenylamino-2-imidazolin-5-one, are preferred.
In the compositions according to the invention, the compound (I)/compound (II) ratio is advantageously chosen so as to produce a synergistic effect. The term synergistic effect is understood to refer in particular to that defined by Colby S.R. in an article entitled “Calculation of the synergistic and antagonistic responses of herbicide combinations” published in the journal Weeds, 1967, 15, p. 20-22. The said article uses the formula:
E=X+Y−XY
/100
in which E represents the expected percentage of inhibition of the disease for the combination of the two fungicides at defined doses (for example equal to x and y respectively), X is the percentage of inhibition observed for the disease by the compound (I) at a defined dose (equal to x), Y is the percentage of inhibition observed for the disease by the compound (II) at a defined dose (equal to y). When the percentage of inhibition observed for the combination is greater than E, there is a synergistic effect.
The term synergistic effect is also understood to refer to that defined by application of the Tammes method, “Isoboles, a graphic representation of synergism in pesticides” Netherlands Journal of Plant Pathology, 70 (1964), p. 73-80.
The ranges of the compound (I)/compound (II) ratio indicated above do not in any way limit the scope of the invention, but are rather mentioned as a guide, a person skilled in the art being entirely capable of carrying out routine experimentation in order to find other values of the ratio of doses of these 2 compounds for which a synergistic effect is observed.
The compositions according to the invention, comprising compound (I) and compound (II), present noteworthy synergistic properties.
In accordance with a preferred variant of the compositions according to the invention, the compound (I)/compound (II) ratio is advantageously from 0.01 to 10, preferably from 0.2 to 5 and even more preferably from 0.3 to 3.
In addition to the compound (I) and the compound (II), the compositions according to the invention comprise an agriculturally acceptable inert support and optionally an agriculturally acceptable surfactant. In the following text, the term active material denotes the combination of the compound (I) with the compound (II), and the percentages quoted are, except where otherwise mentioned, weight/weight percentages.
In the present description, the term “support” denotes an organic or inorganic, natural or synthetic material with which the active material is combined in order to facilitate its application onto the plant or onto the soil. This support is thus generally inert and should be agriculturally acceptable, in particular on the crop treated. The support may be solid (in particular: clays, natural or synthetic silicates, silica, resins, waxes, solid fertilisers) or liquid (in particular: water, alcohols, ketones, petroleum fractions, aromatic or paraffinic hydrocarbons, chloro-hydrocarbons, liquefied gases).
The surfactant may be an emulsifying, dispersing or wetting agent of ionic or non-ionic type.
Mention may be made, for example, of polyacrylic acid salts, lignosulphonic acid salts, phenolsulphonic or naphthalenesulphonic acid salts, polycondensates of ethylene oxide with fatty alcohols or with fatty acids or with fatty amines, substituted phenols (in particular alkylphenols or arylphenols), salts of sulphosuccinic acid esters, taurine derivatives (in particular alkyltaurates) and phosphoric esters of polyoxyethylated phenols or alcohols. The presence of at least one surfactant is often required since the active material and/or the inert support are not water-soluble and the vector agent for the application in water.
These compositions may also contain other ingredients of any kind such as, for example, protective colloids, adhesives, thickeners, thixotropic agents, penetration agents, stabilizers, sequestering agents, pigments, dyes or polymers
More generally, the compositions according to the invention may be combined with any solid or liquid additives corresponding to the usual techniques of agrochemical formulation.
The applica
Chazalet Maurice
Latorse Marie-Pascale
Mercer Richard
Aventis CropScience S.A.
Connolly Bove Lodge and Hutz LLP
Robinson Allen J.
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