Fungicidal composition and method of combating fungi

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514272, 544230, 544298, 544330, 544332, A61K 31505, C07D40512

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active

054629446

ABSTRACT:
Spiroheterocyclic compounds having fungicidal activity are disclosed having the formula: ##STR1## in which X is O or CH.sub.2 ; R.sup.1 is hydrogen or optionally substituted alkyl, cycloalkyl, haloalkyl, alkenyl, alkynyl, aryl or aralkyl; R.sup.2 is optionally substituted alkyl, cycloalkyl, cycloalkylalkyl, alkoxy, alkoxyalkyl, aryl or aryloxy, or together with the ring to which they are attached represents a polycyclic hydrocarbyl group; A and B both represent nitrogen, or A represnts the gorup CR.sup.5 and B represents nitrogen or CR.sup.6 ; 1 is an integer from 1 to 3; m is zero or an integer from 1 to 6; and n represents zero or an integer from 1 to 3.

REFERENCES:
Chemical Abstract vol. 100: 107483, 1988.
Chemical Abstract vol. 96: 205499, 1982.
Bombardt, Paul A. et al., "Liquid Chromatographic Determination of Guanadrel in Laboratory Animal Diet as the Fluorescent Acetylacetone Derivative", Analytical Chemistry, vol. 54, No. 7, pp. 1087-1090, 1982.
Kaiser, D. et al., "Gas Chromatographic Determination of Guanadrel in Plasma and Urine", Journal of Chromatography-Biomedical Applications, vol. 434, No. 1. pp. 135-143, 1988.
Omichi, Kaoru et al., "Linkage Position Analysis of Pyridylamino-Disaccharides by HPLC of Fluorogenic Smith Degradation Products", Journal of Biochemistry, vol. 115, No. 3, pp. 429-434, Mar. 1994.

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