Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1995-06-02
1998-05-05
Lankford, Jr., Leon B.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435 711, 435171, 4352541, 514 11, 514 21, 530317, 530331, 530332, C12P 1710, C12P 2104, A61K 3806, C07K 500
Patent
active
057473048
ABSTRACT:
This invention provides new antifungal compounds of Formula I or II: ##STR1## wherein R, R.sup.1 and R.sup.2 are defined in the specification produced by culture LL-15G256 (Hypoxylon oceanicum), NRRL 21363 and their production by fermentation and use as antifungal agents.
REFERENCES:
"Formulation and Regeneration of Protoplasts Dervied from a Temperature-Sensitive Osmotic Strain of Neurospora crass", Selitrennikoff et al, Expt. Mycology, 5, pp. 155-161 (1981).
"Use of a Temperature-Sensitive, Protoplast-Forming Neurospora crassa Strain for the Detection of anitfungal Antibiotics", Selitrennikoff, Antimicrobial Agents and Chemotherapy, 23, pp. 757-765 (1983).
"A Modified Screen for the Detection of Cell Wall-Acting Antifungal Compounds", Kirsch et al, The Journal of Antibiotics, 39, pp. 1620-1622 (1986).
"Hypoxylon Oceanicum SP. Nov. from Mangroves", Schatz, Mycotaxon, XXXIII, pp. 413-418 (1988).
"Mechanism-Based Screening for the Discovery of Novel Antifungals", D. Kirsch et al, pp. 177-221 in The Discovery of Natural Products with Therapeutic Potential, V. Gullo, Ed., Butterworth-Heinemann, Boston, MA (1993).
Albaugh David A.
Jones E. B. Gareth
Milne Lisa
Pearce Cedric J.
Schlingmann Gerhard
American Cyanamid Company
Costello, Jr. Charles F.
Lankford , Jr. Leon B.
Tate Christopher R.
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