Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-06-28
1997-11-11
Sisson, Bradley L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 911, 435 912, 435921, 435922, 536 231, 536 237, 536 2374, 536 2432, 536 2433, 935 8, 935 76, 935 77, C12Q 168, C12P 1934, C12N 100, C07H 2104
Patent
active
056862482
ABSTRACT:
A polypeptide sequence from Candida albicans is described which has significant sequence homology with known stress proteins from other organisms, particularly the heat shock protein hsp 90 of Saccharomyces cerevisiae. Corresponding DNA sequences are also described, together with antibodies raised against fragments of the sequence. The polypeptide and DNA sequences and antibodies provide separate means for the diagnosis and/or treatment of fungal, particularly Candida, infections.
REFERENCES:
patent: 4806465 (1989-02-01), Buckley et al.
patent: 5288639 (1994-02-01), Burnie et al.
Matthews et al. "Cloning of a DNA sequence encoding a major fragment of the 47 KD stress protein homologue of Candida albicans", FEMS Microbiology Letters 60:25-30, 26 Jun. 1989.
Matthews et al, "Immunoblot analysis of the serological response in systemic candiosis", Lancet, pp. 1415-1418, 22/29 Dec. 1984.
Burnie et al, Lancet "47 KD antigen of Candida albicans," pp. 1155, 18 May 1985.
Farrelly et al, "Complete sequence of the heat shock-inducible HSP90 gene of Saccharomyces cerivisiae", The Journal of Biological Chemistry, 259(9):5745-5751, 10 May 1984.
Matthews et al, "Isolation of immunodominant antigens from sera of patients with systemic candidiasis and characterisation of serological response to Candida albicans" Journal of Clinical Microbiol, . 25(2):230-237, 1987.
Matthews et al, "Characterisation and cellular localisation of immunodominant 47 KDa antigen of Candida albicans", Journal of Medical microbiology, 27:227-232, 1988.
Neale et al, "The immunochemical characterisation of circulating immune complex constituents in Candida albicans osteomyelitis by isoelectric focusing, immunoblot and immunoprint", Aust. NZ. J. Med., 17:201-208, 1987.
Matthews et al., "Diagnosis of Systemic Candidiasis by an Enzyme-Linked Dot Immunobinding Assay for a Circulating Immunodominant 47-kilodalton Antigen", J. Clin. Microbial, 26(3):459-463 (Mar. 1988).
Dragon et al, "The Genome of Trypanosoma cruzi Contains a Constitutively Expressed, Randomly Arranged Multicopy Gene Homologous to a Major Heat Shock Protein", Mol. Ceel. Biol. 7(3):1271-1275 (Mar. 1987).
Matthews & Burnie, "Cloning of a DNA Sequence Encoding a Major Fragment of the 47 Kilodalton Stress Protein Homoloque of Candida Albicus", FEMS Microbiol. Letters, 60:25-30 (Jul. 1, 1989).
Burnie James Peter
Matthews Ruth Christine
Sisson Bradley L.
The Victoria University of Manchester
LandOfFree
Fungal stress proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Fungal stress proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fungal stress proteins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1227830