Fungal strains and use thereof in antibiotic production

Details Fungal strains and use thereof in antibiotic production Fungal strains and use thereof in antibiotic production

1992-11-30

1994-11-08

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

4351722, 4351723, 4352543, 4352561, 435913, 435918, 935 52, 935 56, 935 60, 935 68, C12P 1706, C12N 1510, C12N 1580, C12N 115

Patent

active

053626389

ABSTRACT:
Lovastatin is produced by a process of fermentation using a fungal transformant produced by introducing into a non-lovastatin expressing Aspergillus strain such as a strain of Aspergillus oryzae the DNA of a lovastatin-expressing strain of Aspergillus terreus .

REFERENCES:
patent: 4294926 (1981-10-01), Monaghan et al.
patent: 4399216 (1983-08-01), Axel et al.
J. F. Martin et al. "Organization and Expression of Genes Involved in the Biosynthesis of Antibiotics and other Secondary Metabolits" Ann. Rev. Microbiol. 43:173-206 (1989).
Gullo, V. P. et al. "High-Performance Liquid Chromatographic Analysis . . . " J. Chromatography 212:234-238 (1981).
Y. T. Hahn et al. "Genetic Transformation of a Arg B Mutant . . . " Appl. Environ. Microbiol. 54:1610-1611 (Jun. 1988).

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