Fungal negative microorganism capable of producing high levels o

Details Fungal negative microorganism capable of producing high levels o Fungal negative microorganism capable of producing high levels o

1992-03-27

1994-07-12

Knode, Marian

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Fungi

435 67, 435171, 435911, C12N 114

Patent

active

053288459

ABSTRACT:
The present invention is directed toward a method for producing beta-carotene using negative (minus mating type) Mucorales fungal microorganisms. The method includes mutating and selecting negative Mucorales fungal microorganisms, culturing the selected negative microorganisms in an effective medium to produce beta-carotene, and recovering beta-carotene therefrom. The present invention provides negative microorganisms that overproduce beta-carotene, beta-carotene formulations produced by the disclosed method, and the use of such formulations to enhance pigmentation, to reduce damage caused by reactive oxygen species or phototoxic molecules, to prevent or treat cancer or cardiovascular disease, to provide a Vitamin A supplement, to enhance lactation, and to increase fertility.

REFERENCES:
patent: 2865814 (1958-12-01), Hesseltine et al.
patent: 2890989 (1959-06-01), Anderson
patent: 2910410 (1959-10-01), Corman
patent: 2959521 (1960-11-01), Zajic
patent: 2959522 (1960-11-01), Zajic
patent: 3001912 (1961-09-01), Miescher
patent: 3095357 (1963-06-01), Fulde
patent: 3226302 (1965-12-01), Ciegler
patent: 3235467 (1966-02-01), Ninet et al.
patent: 3242054 (1966-03-01), Ninet et al.
patent: 3291701 (1966-12-01), Fulde
patent: 3378460 (1968-04-01), Ninet et al.
patent: 3421980 (1969-01-01), Ninet et al.
patent: 3492202 (1970-01-01), Bohinski
patent: 3522146 (1970-07-01), Jager
patent: 4318987 (1982-03-01), Murillo et al.
Candau et al., "In Vivo channeling of Substrates in an Enzyme Aggregate for .beta.-carotene Biosynthesis," PNAS, vol. 88, pp. 4936-4940, 1991.
Jacobson, G., "Mutations", Biotechnology, vol. 1, Rehm et al. eds.; Published by Verlag Chemie, 1981.
Creuger, W. et al., "Strain Development", In Biotechnology: A Textbook of Industrial Microbiology, Published: Sinaw Associates, pp. 9-17, 1984.
Lewis, M. J. et al., "Selection of Astaxanthin-Overproducing Mutants of Phaffia rhodozyma with .beta.-Ionone", Appl. Environment Microbiol, vol. 56, No. 9, pp. 2944-2945, 1990.
Nelis et al., "Microbial Sources of Carotenoid Pigments Used in Foods and Feeds", pp. 181-191, 1991, Journal of Applied Bacteriology, vol. 70.
Murillo et al., "Carotene-Superproducing Strains of Phycomyces", pp. 639-642, 1978, Appl. Environ. Microbiol., vol. 36.
Salgado et al., "Carotene-Superproducing Mutants of Phycomyces blakesleeanus", pp. 332-336, 1989, Experimental Mycology, vol. 13.
Lampila et al., "A Review of Factors Affecting Biosynthesis of Carotenoids by the Order Mucorales", pp. 65-80, 1985, Mycopathologia, vol. 90.
Cerda-Olmedo, "Production of Carotenoids with Fungi", pp. 27-42, 1989, Biotechnology of Vitamins, Pigments, and Growth Factors, (E. Vandamme, ed).

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