Fungal multisubunit protein complex critical for expression of f

Details Fungal multisubunit protein complex critical for expression of f Fungal multisubunit protein complex critical for expression of f

1994-09-19

1998-12-08

Ketter, James

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530300, 530324, 530325, 530326, 530327, 530328, 530329, 530330, 530350, C07K 1439, C07K 406, C07K 704, C07K 1437

Patent

active

058470778

ABSTRACT:
The present invention provides a complex of fungal polypeptides, termed TAFs, that are necessary for activated transcription in fungi such as S. cerevisiae. The complex comprises at least nine associated subunit polypeptides, having molecular masses of about 180 kDa, 145 kDa, 116 kDa, 90 kDa, 68 kDa, 51-54 kDa, 47 kDa, and 30 kDa, respectively. TAF-145, having the sequence set forth in FIG. 6B, binds TATA-box Binding Protein (TBP). The invention also includes nucleic acid sequences encoding TAF-145, as well as DNA vectors and transformed cells suitable for recombinant expression of this polypeptide.

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