Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-04-21
2009-06-02
Carlson, Karen Cochrane (Department: 1656)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C424S001130, C424S278100, C530S350000
Reexamination Certificate
active
07541332
ABSTRACT:
A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed. Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.
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Hata Katsura
Kai Junko
Nakamoto Kazutaka
Ohba Fuminori
Sagane Koji
Carlson Karen Cochrane
Eisai R&D Management Co., Ltd.
Liu Samuel W.
Townsend and Townsend / and Crew LLP
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