Fungal cell wall synthesis gene

Details Fungal cell wall synthesis gene Fungal cell wall synthesis gene

2011-04-19

2011-04-19

Desai, Anand U (Department: 1656)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S254100, C435S007310, C435S320100, C435S069100, C514S002600

Reexamination Certificate

active

07928209

ABSTRACT:
A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, fungal genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed. These genes encode proteins participating in fungal cell wall synthesis. Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.

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