Fungal cell wall synthesis gene

Details Fungal cell wall synthesis gene Fungal cell wall synthesis gene

2011-03-01

2011-03-01

Desai, Anand U (Department: 1656)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Animal cell, per se, expressing immunoglobulin, antibody, or...

C435S254100, C435S007310, C435S911000, C514S002600, C514S001100, C530S350000, C536S069000, C536S063000, C536S023100

Reexamination Certificate

active

07897387

ABSTRACT:
A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed. Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.

REFERENCES:
patent: 4013666 (1977-03-01), Lenz
patent: 5525716 (1996-06-01), Olsen et al.
patent: 5641627 (1997-06-01), Moehle
patent: 5648465 (1997-07-01), Margolis et al.
patent: 5962252 (1999-10-01), McFarland et al.
patent: 5969102 (1999-10-01), Bram et al.
patent: 6747137 (2004-06-01), Weinstock et al.
patent: 6833447 (2004-12-01), Goldman et al.
patent: 7375204 (2008-05-01), Tsukahara et al.
patent: 2002/0072051 (2002-06-01), Bulawa et al.
patent: 2004/0029129 (2004-02-01), Wang et al.
patent: 2006/0172404 (2006-08-01), Hata et al.
patent: 2006/0234283 (2006-10-01), Tsukahara et al.
patent: 2006/0234349 (2006-10-01), Tsukahara et al.
patent: 2006/0240429 (2006-10-01), Tsukahara et al.
patent: 2006/0280725 (2006-12-01), Bode
patent: 2007/0287151 (2007-12-01), Linnarsson
patent: 2008/0166765 (2008-07-01), Tsukahara et al.
patent: 2008/0261272 (2008-10-01), Tsukahara et al.
patent: 2009/0098636 (2009-04-01), Tsukahara et al.
patent: 2009/0325228 (2009-12-01), Tsukahara et al.
patent: WO 94/01567 (1994-01-01), None
patent: WO 99/39197 (1999-08-01), None
patent: WO 00/01387 (2000-01-01), None
Zhnag et al. (1996) An analysis of base frequencies in the anti-sense strands corresponding to the 180 human protein coding sequences, Amino acids, vol. 10, pp. 253-262.
Umemura et al. (2003) GWT1 gene is required for inositol acylation of glycosylphosphatidylinositol anchors in yeast, J. Biol. Chem., vol. 278, No. 26, pp. 23639-23647.
White et al. ((1998) Clinical, cellular, and molecular factors that contribute to antifungal drug resistance, Clin. Microbiol. Rev., vol. 11, No. 2, pp. 382-402.
Futeman A. H. (1993) Inhibition of sphingolipid synthesis: effects on glycosphingolipid-GPI-anchored protein microdomains, Trends Cell Biol., vol. 5, No. 10, pp. 377-380.
Mohuczy, D., et al., “Delivery of Antisense DNA by Vectors for Prolonged Effects in Vitro and in Vivo,”Methods in Enzymology, vol. 314, pp. 32-51 (2000).
Van Der Vaart, J. M., et al., “Identification of Three Mannoproteins in the Cell Wall ofSaccharomyces cerevisiae” Journal of Bacteriology, Jun. 1995. pp. 3104-3110, vol. 177, No. 11, American Society of Microbiology.
Wikipedia (2007, updated) Homology (biology) http://en.wikipedia.org/wiki/Homology˜(biology), p. 1.
Attachment 1 (2005) Sequence alignment between nucleotide sequences of instant SEQ ID No. 3 and SEQ ID No. 998 of US Pat. No. 6,747,137, pp. 1-4.
Database EMBL Online; Accession No. AL132675; Created on Oct. 27, 1999; Description: S.pombe Chromosome I Cosmid c144, 9 pages.
Davila, J.C. et al.; “Cytotoxicity induced by papaverine hydrochloride in fungal cell systems”; 1990,Toxicology Letter, vol. 54, pp. 23-31.
Prostakov, N.S. et al.; 1980,Khim Geterotsikl Soedin, vol. 5, pp. 673-676.
Seow, W.K. et al.; 1993,Chemical Abstracts, vol. 119, No. 23, p. 32.
Seow, W.K. et al.; “Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumor necrosis factor-alpha”; 1993,Mediators of Inflammation, vol. 2, pp. 199-203.
Shiotani, Shunsaku et al.; “Wittig-Horner Reaction of a Phosphonate of Reissert Analogues of Furo”; 1997,J. Heterocyclic Chemistry, vol. 34, No. 1, pp. 129-141.
Skrzypek, M., et al., Suppressor Gene Analysis Reveals an Essential Role for Sphingolipids in Transport of Glycosylphosphatidylinositol-Anchored Proteins inSaccharomyces cerevisiae, Journal of Bacteriology, vol. 179(5), pp. 1513-1520 (Mar. 1997).
Smirnov, L.D. et al.; 1974,Khim Geterotsiki, vol. 8, pp. 1094-1095.
Smirnov, L.D. et al.; 1975,Chemical Abstracts, vol. 82, No. 3, p. 484.
Sütterlin, C., et al., “Saccharomyces cerevisiaeGPI10, the functional homologue of human PIG-B, is required for glycosylphosphatidylinositol anchor synthesis,” 1998,Biochem. J., vol. 332 (Pt 1), pp. 153-159.
Tsai, I.L. et al.; “Screening of Isoquinoline Alkaloids and their Derivatives for Antibacterial and Antifungal Activities”; 1989,Kalhslung J. Med. Sci., vol. 5, pp. 132-145.
Tsai, I.L. et al.; 1989,Chemical Abstracts, vol. 111, No. 5, p. 342.
Anderson, P., et al “DNA Quality Control for Oligonucleotide Array CGH (aCGH) with the Agilent 2100 Bioanalyzer,” pp. 1-10 (2005).
Miosga, et al.; GenBank Accession No, CAA89384 http://www.ncbi.nim.nih.gov/protein/1008262 ,1997.
GenBank No. CA859690, Oct. 1999, 2 pages.
Hamada, K., et al., “Screening for Glycosylphoshpatidylinositol (GPI)-Dependent Cell Wall Proteins inSaccharomyces cerevisiae,” Molecular and General Genetices, Apr. 1998, pp. 53-59, vol. 258, No. 1-2, Springer-Verlag.
Ikezawa, H., et al., “Glycosylphosphatidylinositol (GPI)-anchored proteins,” 2002,Biol. Pharm. Bull., vol. 25(4), pp. 409-417.
Mamyrbekova, Z.A. et al.; “Synthesis, structure, and biological activity of paracyclophane derivatives”, 1995,Chemical Abstracts, vol. 123, p. 592.
Mamyrbekova, Z.A. et al.; 1994,Khim Pharm., vol. 28, No. 3, pp. 48-51.
Miosga, et al., “Sequence Analysis Of A 33-1 kb Fragment From The Left Arm OfSaccharomyces cerevisiaeChromosome X, Including Putative Proteins With Leucine Zippers, A Fungal Zn(II)2-Cys6Binuclear Cluster Domain And A Putative α2-SCB-α2 Binding Site”,Yeast, vol. 11: 681-689 (1995).
Miosga, T. et al.; “GPI-anchored wall transfer protein 1 (Inositol acyltransferase GWT1)”;GenBank Database; Acession No. P47026, 2009, updated.
Miosga, T. et al.; “S. cerevisiaechromosome X reading frame ORF YJL091c”;GenBank Database: Aug. 11, 1997; Accession No. Z49366.
Mohuczy, D., et al., “Delivery of Antisense DNA by Vectors for Prolonged Effects in Vitro and in Vivo,”Methods in Enzymology, vol. 314, pp. 32-51 (1999).
Prostakov, N.S. et al.; 1980,Chemical Abstractsvol. 93, No. 17, p. 660.
Tsukahara, K., et al., “Medicinal Genetics Approach Towards Identifying the Molecular Target of a Novel Inhibitor of Fungal Cell Wall Assembly,”Molecular Microbiology, May 2003, pp. 1029-1042, vol. 48, No. 4, Blackwell Publishing Ltd.
Umemura, et al., “GWT1gene is required for inositol acylation of glycosylphospha-tidylinositol anchors in yeast,” 2003,Biol. Chem., vol. 278(26), pp. 23639-23647.
White et al., “Clinical, Cellular, and Molecular factors that contribute to Antifungal drug resistance,” 1998,Clin. Microbiol Rev., vol. 11(2), pp. 382-402.
Wikipidia (2007, updated) Homology (biology) http://en.wikipedia.org/wikilHomology˜(biology), p. 1.
Wiktionary (2007, updated) “transformant” http://en.wiktionary.org/wiki/transformant,p. 1, Accessed: Jan. 22, 2008 http://en.wiktionary.org/w/index.php?title=transformant&printable=yes.

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