Functionally specific antibodies

Details Functionally specific antibodies Functionally specific antibodies

1988-02-26

1989-09-19

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, A61K 4902

Patent

active

048679623

ABSTRACT:
Diagnostic or therapeutic agents are attached to two or more antibody species having non-overlapping patterns of cross-reactivity to increase the relative amount of the active agent(s) delivered to desired target cells compared to non-target cells. The agents may be attached to monoclonal antibodies which bind to cancer cells so that a higher percentage of the active agent(s) localize on the target cells compared to each type of cross-reactive normal tissue.

REFERENCES:
patent: 4478815 (1984-10-01), Burchiel et al.
patent: 4624846 (1986-11-01), Goldenberg

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