Functionally active selectin-derived peptides

Details Functionally active selectin-derived peptides Functionally active selectin-derived peptides

1992-04-07

1993-03-30

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 14, 514 15, 514 16, 530324, 530325, 530326, 530327, 424 11, 623 11, A61K 3700, A61K 4300, C07K 500, C07K 700

Patent

active

051984245

ABSTRACT:
Peptides derived from three regions of the lectin binding region of GMP-140 have been found to selectively interact with "selectins", including GMP-140, ELAM-1, and lymphocyte homing receptor. The peptides can be as short as eight to thirteen amino acids in length and are easily prepared and modified by standard techniques. Critical elements of the counter-receptor or ligand on the neutrophils which binds GMP-140 are also identified. The peptides are useful as diagnostics and

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