Functionally active regions of signal transducer and activators

Details Functionally active regions of signal transducer and activators Functionally active regions of signal transducer and activators

1995-01-06

1998-02-10

Chan, Christina

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

4241931, 530350, 530403, A61K 39385, C07K 14715, C07K 1702

Patent

active

057166226

ABSTRACT:
The present invention relates generally to intracellular receptor recognition proteins or factors, termed Signal Transducers and Activators of Transcription (STAT), to methods and compositions utilizing such factors, and to the antibodies reactive toward them, in assays and for diagnosing, preventing and/or treating cellular debilitation, derangement or dysfunction. More particularly, the present invention relates to particular functional domains of molecules that exhibit both receptor recognition and message delivery via DNA binding in receptor-ligand specific manner, i.e., that directly participate both in the interaction with the ligand-bound receptor at the cell surface and in the activity of transcription in the nucleus as a DNA binding protein. The invention likewise relates to the antibodies and other entities that are specific to the functional domain of a STAT protein and that would thereby selectively modulate its activity.

REFERENCES:
Darnell et al., 1994, Science 264:1415-1421.
Improta et al., 1994, Proc. Natl. Acad. Sci. USA 91:4776-80.
Shuai et al., 1994, Cell 76:821-28.
Zhong et al., 1994, Proc. Natl. Acad. Sci. USA 91:4806-4810.
Zhong et al., 1994, Science 264:95-98.
Eck et al., 1993, Nature 362:87-91.
Felder et al., 1993, Mol. Cell. Biol. 13:1449-55.
Khan et al., 1993, Proc. Natl. Acad. Sci. USA 90:6806-10.
Muller et al., 1993, EMBO J. 12:4221-28.
Muller et al., 1993, Nature 366:129-35.
Pearse et al., 1993, Proc. Natl. Acad. Sci. 90:4314-18.
Sadowski et al., 1993, Nature 362:79-83.
Sadowski et al., 1993, Science 261:1739-44.
Shuai et al., 1993, Nature 366:580-83.
Shuai et al., 1993, Science 261:1744-46.
Songyang et al., 1993, Cell 72:767-78.
Watling et al., 1993, Nature 366:166-70.
Wegenka et al., 1993, Mol. Cell. Biol. 13:276-88.
Schindler et al., 1992, Proc. Natl. Acad. Sci. USA 89:7836-39.
Schindler et al., 1992, Science 257:809-13.
Decker et al., 1991, EMBO J. 10:927-32.
Lew et al., 1991, Mol. Cell. Biol. 11:182-91.
Fu et al., 1990, Proc. Natl. Acad. Sci. USA 87:8555-59.
Wagner et al., 1990, EMBO J. 9:4477-84.

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