Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1993-07-02
1995-04-11
Hollinden,, Gary
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
436173, 1286534, 534 15, 534 16, 514492, 514504, 514836, 556 45, 556 50, 556 51, 556 63, 556 81, 556107, 556110, 556116, 556118, 556134, 556136, 556147, 556148, 562 12, 562 20, 562101, 562582, 562590, A61B 5055, C07C 59245, C07C 5500
Patent
active
054056012
ABSTRACT:
The present invention provides new and structurally diverse compositions for diagnostic imaging comprising compounds of the general formula: ##STR1## wherein A is N or CR.sub.1, R.sub.1 is hydrogen, C.sub.1 -C.sub.8 alkyl, or C.sub.6 -C.sub.10 aryl, where the alkyl or aryl group may be optionally substituted with one or more hydroxy, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 hydroxyalkyl, C.sub.1 -C.sub.8 alkoxy, C.sub.6 -C.sub.10 aryl, C.sub.6 -C.sub.10 hydroxyaryl, C.sub.6 -C.sub.10 aryloxy, --CO.sub.2 R.sub.2, --CONR.sub.3 R.sub.4, or NR.sub.3 R.sub.4 ; D is O, --O(CH.sub.2).sub.2 O--, --O(CH.sub.2).sub.3 O--, or NR.sub.5 ; E is O, --O(CH.sub.2).sub.2 O--, --O(CH.sub.2).sub.3 O-- or NR.sub.6 ; F is O, --O(CH.sub.2).sub.2 O--, --O(CH.sub.2).sub.3 O-- or NR.sub.7 ; R.sub.2 -R.sub.7 are as defined within; g, h, i, j, k and m may be the same or different and are an integer from one to about six; X is --CO.sub.2 H, --PO.sub.3 H.sub.2, --SO.sub.3 H or --CONHOH.
REFERENCES:
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Matsumura, S; Yukagaku, 28(6):403-406, (1979).
Chiu, KW et al. Chem Abstracts, 117:146345x (1992).
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Dunn T. Jeffrey
Moore Dennis A.
Periasamy Muthanadar
Rogic Milorad M.
Wallace Rebecca A.
Hollinden Gary
Mallinckrodt Medical Inc.
Stierwalt Brian K.
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