Functionalized tripodal ligands for imaging applications

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

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436173, 1286534, 534 15, 534 16, 514492, 514504, 514836, 556 45, 556 50, 556 51, 556 63, 556 81, 556107, 556110, 556116, 556118, 556134, 556136, 556147, 556148, 562 12, 562 20, 562101, 562582, 562590, A61B 5055, C07C 59245, C07C 5500

Patent

active

054056012

ABSTRACT:
The present invention provides new and structurally diverse compositions for diagnostic imaging comprising compounds of the general formula: ##STR1## wherein A is N or CR.sub.1, R.sub.1 is hydrogen, C.sub.1 -C.sub.8 alkyl, or C.sub.6 -C.sub.10 aryl, where the alkyl or aryl group may be optionally substituted with one or more hydroxy, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 hydroxyalkyl, C.sub.1 -C.sub.8 alkoxy, C.sub.6 -C.sub.10 aryl, C.sub.6 -C.sub.10 hydroxyaryl, C.sub.6 -C.sub.10 aryloxy, --CO.sub.2 R.sub.2, --CONR.sub.3 R.sub.4, or NR.sub.3 R.sub.4 ; D is O, --O(CH.sub.2).sub.2 O--, --O(CH.sub.2).sub.3 O--, or NR.sub.5 ; E is O, --O(CH.sub.2).sub.2 O--, --O(CH.sub.2).sub.3 O-- or NR.sub.6 ; F is O, --O(CH.sub.2).sub.2 O--, --O(CH.sub.2).sub.3 O-- or NR.sub.7 ; R.sub.2 -R.sub.7 are as defined within; g, h, i, j, k and m may be the same or different and are an integer from one to about six; X is --CO.sub.2 H, --PO.sub.3 H.sub.2, --SO.sub.3 H or --CONHOH.

REFERENCES:
patent: 3725290 (1973-04-01), Nelson et al.
Matsumura, S; Yukagaku, 28(6):403-406, (1979).
Chiu, KW et al. Chem Abstracts, 117:146345x (1992).
Smith et al. Inorganic Chemistry, 27(22):3929-3934 (1988).

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