Functionalized silicon compounds and methods for their...

Details Functionalized silicon compounds and methods for their... Functionalized silicon compounds and methods for their...

2006-08-29

2006-08-29

Riley, Jezia (Department: 1637)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From silicon reactant having at least one...

C528S025000, C528S028000, C528S033000

Reexamination Certificate

active

07098286

ABSTRACT:
Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino, carboxyl and thiol, as well as modified forms thereof, such as activated or protected forms. The functionalized silicon compounds may be covalently attached to surfaces to form functionalized surfaces which may be used in a wide range of different applications. In one embodiment, the silicon compounds are attached to the surface of a substrate comprising silica, such as a glass substrate, to provide a functionalized surface on the substrate, to which molecules, including polypeptides and nucleic acids, may be attached. In one embodiment, after covalent attachment of a functionalized silicon compound to the surface of a solid silica substrate to form a functionalized coating on the substrate, an array of nucleic acids may be covalently attached to the substrate. Thus, the method permits the formation of high density arrays of nucleic acids immobilized on a substrate, which may be used, for example, in conducting high volume nucleic acid hybridization assays.

REFERENCES:
patent: 3285886 (1966-11-01), Gunderson et al.
patent: 4448694 (1984-05-01), Plueddemann
patent: 4526996 (1985-07-01), Kilgour et al.
patent: 4990641 (1991-02-01), Kabeta
patent: 5013771 (1991-05-01), Guillet et al.
patent: 5079600 (1992-01-01), Schnur et al.
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5200051 (1993-04-01), Cozzette et al.
patent: 5206285 (1993-04-01), Castellucci
patent: 5252743 (1993-10-01), Barrett et al.
patent: 5324591 (1994-06-01), Georger, Jr. et al.
patent: 5324663 (1994-06-01), Lowe
patent: 5384261 (1995-01-01), Winkler et al.
patent: 5393353 (1995-02-01), Bishop
patent: 5405783 (1995-04-01), Pirrung et al.
patent: 5412087 (1995-05-01), McGall et al.
patent: 5424186 (1995-06-01), Fodor et al.
patent: 5445934 (1995-08-01), Fodor et al.
patent: 5451683 (1995-09-01), Barrett et al.
patent: 5510270 (1996-04-01), Fodor et al.
patent: 5527681 (1996-06-01), Holmes
patent: 5545531 (1996-08-01), Rava et al.
patent: 5547839 (1996-08-01), Dower et al.
patent: 5571639 (1996-11-01), Hubbell et al.
patent: 5578832 (1996-11-01), Trulson et al.
patent: 5599695 (1997-02-01), Pease et al.
patent: 5624711 (1997-04-01), Sundberg et al.
patent: 5631734 (1997-05-01), Stern et al.
patent: 5677195 (1997-10-01), Winkler et al.
patent: 5700637 (1997-12-01), Southern
patent: 5710000 (1998-01-01), Sapolsky et al.
patent: 5744101 (1998-04-01), Fodor et al.
patent: 5744305 (1998-04-01), Fodor et al.
patent: 5779904 (1998-07-01), Ruderman et al.
patent: 6262216 (2001-07-01), McGall
patent: 6410675 (2002-06-01), McGall et al.
patent: 6429275 (2002-08-01), McGall et al.
patent: 6486287 (2002-11-01), McGall et al.
patent: 6743882 (2004-06-01), McGall et al.
patent: 2004/0215031 (2004-10-01), McGall et al.
patent: 2004/0253460 (2004-12-01), McGall et al.
patent: 2005/0123775 (2005-06-01), McGall et al.
patent: 1238997 (1988-07-01), None
patent: 21 44 759 (1972-03-01), None
patent: 28 21 016 (1978-11-01), None
patent: 35 00 576 (1985-07-01), None
patent: 0 011 782 (1980-06-01), None
patent: 0 136 680 (1985-04-01), None
patent: 0 368 279 (1990-03-01), None
patent: 0 862 068 (1998-09-01), None
patent: 60-169847 (1985-09-01), None
patent: 05-004994 (1993-01-01), None
patent: 05-320517 (1993-12-01), None
patent: 07-102167 (1995-04-01), None
patent: 07-157971 (1995-06-01), None
patent: 07-310006 (1995-11-01), None
patent: 07-331014 (1995-12-01), None
patent: WO 89/10977 (1989-11-01), None
patent: WO 92/10092 (1992-06-01), None
patent: WO 95/15740 (1995-05-01), None
patent: WO 97/10365 (1997-03-01), None
patent: WO 97/39151 (1997-10-01), None
patent: WO 98/11092 (1998-03-01), None
patent: WO 00/21967 (2000-04-01), None
Arkles, B., “Tailoring Surfaces with Silanes” Chemtech 7:766-778 (1977).
Barber, H.J. (1943). “Some sulphonyl derivatives of amidines and imino-ethers,” J. Chem. Sci. 10:101-104.
Barbot, F. (1989). “N-tosyl iminoethers et iminocarbonates d'alkyle: Synthons d'amines primaires a structure ramifiee,” Tetrahedron Lett. 30:185-186.
Beckwith, A.C.J. et al. (1975). “Cyclization of 3-allylhex-5-enyl radical: Mechanism, and implications concerning the structures of cyclopolymers,” J. Chem. Soc. Perkin Trans. II:1726-1733.
Bos et al., “Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia” Nature 315:726-730 (1985).
Bubnov, Y.N. et al. (1996). “Synthesis of compounds of the triallylmethane series based on reactions of triallyborane and derivatives of carbonic acid,” Russ. Chem. Bull. 45:2598-2601.
Chee, M. et al., “Accessing genetic information with high-density DNA arrays” Science 274:610-614 (Oct. 25, 1996).
Chujo, Y. et al. (1993). “Synthesis of triethoxysilyl-terminated polyoxazolines and their cohydrolysis polymerization with tetraethoxysilane,” Macromolecules. 26(21):5681-5686.
Curran, D.P. et al. (1991). “The tin hydride reductive decyanation of geminal dinitriles,” Synthesis Letts. 107-108.
de Saizeu, A. et al., “Bacterial transcript imaging by hybridization of total RNA to oligonucleotide arrays” Nature Biotechnol. 16:45-48 (1998).
Dreyfuss, M.P. (1963). “A convenient method for utilizing the allyl grignard reagent,” J. Org. Chem. 28:3269-3272.
Elder, J.K., “Analysis of DNA Oligonucleotide Hybridization Data by Maximum Entropy,” in: Maximum Entropy and Bayesian Methods, eds. Mohammad-Djafari and Demoment, Kluwer Academic Publ., Dordrecht, NL, pp. 363-371 (1992).
Hochgeschwender, U. et al., “Preferential expression of a defined T-cell receptor .beta.-chain gene in hapten-specific cytotoxic T-cell clones” Nature 322:376-378 (1986).
Hong, S.G. et al., “Investigation of primers reducing the pink-ring formation in multilayer printed circuit boards” Department of Chemical Engineering, Yuan-Ze Institute Technology Nei-Li, Tao-Yuan, 320, Taiwan, Die Angewandte Makromolekulare Chemie 231, pp. 91-108 (1995) Article in English.
Kabeta, K. (Jul. 30, 1990). “Patent Abstract: Preparation of N, N-bis (alkoxysilylpropyl) aminohydrocabyl amines,” Chemical Abstracts 113(5):abstract No. 41014. Corresponds to Japanese Patent 02 019385.
Kirkland, J.J. et al., “Synthesis and Characterization of Highly Stable Bonded Phases for High-Performance Liquid Chromatography Column Packings” Anal. Chem. 61:2-11 (1989).
Lockhart, D.J. et al., “Expression monitoring by hybridization to high-density oligonucleotide arrays” Nature Biotechnol. 14:1675-1680 (Dec. 1996).
McGall, G. et al., “Light-directed synthesis of high-density oligonucleotide arrays using semiconductor photoresists” Proc. Natl. Acad. Sci. USA 93:13555-13560 (1996).
McGall, G.H. et al., “The Efficiency of Light-Directed Synthesis of DNA Arrays on Glass Substrates” J. Am. Chem. Soc. 119(22):5081-5090 (1997).
Pease, A.C. et al., “Light-generated oligonucleotide arrays for rapid DNA sequence analysis” Proc. Natl. Acad. Sci. USA 91:5022-5026 (1994).
Reeve, W. (1969). “Synthesis of tetraallylmethane,” J. Org. Chem. 34:1921-1923.
Schneider, P. et al., “Tailor-Made Silylating Agents for Efficient Surface Modification” Synthesis, pp. 1027-1031 (1990).
Southern E.M. et al., “Analyzing and Comparing Nucleic Acid Sequences by Hybridization to Arrays Oligonucleotides: Evaluation Using Experimental Models” Genomics 13: 1008-1017 (1992).
Verlaan-de Vries, M. et al., “A dot-blot screening procedure for mutated ras oncogenes using synthetic oligodeoxynucleotides” Gene 50:313-320 (1986).

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