Functionalized polymer for oligonucleotide purification

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Polymers from only ethylenic monomers or processes of...

Reexamination Certificate

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C526S242000, C526S296000, C210S635000, C210S634000, C210S679000, C435S803000

Reexamination Certificate

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07125945

ABSTRACT:
Halogenated polymers of vinyl aromatic monomers comprising styrene and divinylbenzene are provided for use in a chromatographic separation method of analytes, wherein said polymer further comprises a hydrocarbyl or halocarbyl substituent comprising from 1 to 1,000,000 carbon atoms, or combinations thereof. Methods of using the halogenated polymers are also provided. The polymers and methods are particularly useful in the separation of nucleic acids labeled with hydrophobic labels such as protecting groups, fluorophores, and the like.

REFERENCES:
patent: 4352909 (1982-10-01), Barda et al.
patent: 4469863 (1984-09-01), Ts'o et al.
patent: 4725677 (1988-02-01), Koster et al.
patent: 4774339 (1988-09-01), Haugland et al.
patent: 5034506 (1991-07-01), Summerton et al.
patent: 5124047 (1992-06-01), Quach et al.
patent: 5138045 (1992-08-01), Cook et al.
patent: RE34069 (1992-09-01), Koster et al.
patent: 5187288 (1993-02-01), Kang et al.
patent: 5214134 (1993-05-01), Weis et al.
patent: 5216141 (1993-06-01), Benner
patent: 5218105 (1993-06-01), Cook et al.
patent: 5223618 (1993-06-01), Cook et al.
patent: 5248782 (1993-09-01), Haugland et al.
patent: 5264562 (1993-11-01), Matteucci
patent: 5274113 (1993-12-01), Kang et al.
patent: 5278302 (1994-01-01), Caruthers et al.
patent: 5321131 (1994-06-01), Agrawal et al.
patent: 5359044 (1994-10-01), Cook et al.
patent: 5378825 (1995-01-01), Cook et al.
patent: 5386023 (1995-01-01), Sanghvi et al.
patent: 5433896 (1995-07-01), Kang et al.
patent: 5434257 (1995-07-01), Matteucci et al.
patent: 5451663 (1995-09-01), Kang et al.
patent: 5455233 (1995-10-01), Spielvogel et al.
patent: 5457191 (1995-10-01), Cook et al.
patent: 5459255 (1995-10-01), Cook et al.
patent: 5466677 (1995-11-01), Baxter et al.
patent: 5470967 (1995-11-01), Huie et al.
patent: 5489677 (1996-02-01), Sanghvi et al.
patent: 5506351 (1996-04-01), McGee
patent: 5519126 (1996-05-01), Hecht
patent: 5541307 (1996-07-01), Cook et al.
patent: 5543507 (1996-08-01), Cook et al.
patent: 5571902 (1996-11-01), Ravikumar et al.
patent: 5578718 (1996-11-01), Cook et al.
patent: 5585236 (1996-12-01), Bonn et al.
patent: 5587361 (1996-12-01), Cook et al.
patent: 5587469 (1996-12-01), Cook et al.
patent: 5587470 (1996-12-01), Cook et al.
patent: 5596086 (1997-01-01), Matteucci et al.
patent: 5602240 (1997-02-01), De Mesmaeker et al.
patent: 5610289 (1997-03-01), Cook et al.
patent: 5614617 (1997-03-01), Cook et al.
patent: 5670633 (1997-09-01), Cook et al.
patent: 5792608 (1998-08-01), Swaminathan et al.
patent: 5817781 (1998-10-01), Swaminathan et al.
patent: 5882551 (1999-03-01), Dever et al.
patent: 6156896 (2000-12-01), Curran et al.
patent: 6288157 (2001-09-01), Jariwala et al.
patent: 6320040 (2001-11-01), Cook et al.
patent: 6355791 (2002-03-01), Gjerde et al.
patent: 6447749 (2002-09-01), Licha et al.
patent: 6518368 (2003-02-01), Gill et al.
patent: 6521714 (2003-02-01), Kolich et al.
patent: 6525127 (2003-02-01), Jariwala et al.
patent: 2003/0055241 (2003-03-01), Moore et al.
patent: WO 86/05518 (1986-09-01), None
patent: WO 90/15065 (1990-12-01), None
patent: WO 91/18997 (1991-12-01), None
patent: WO 92/05186 (1992-04-01), None
Abstract by Haung, GJ and Krugh, TR, entitled “Large Scale Purification of Synthetic Oligonucleotides and Carcinogen-modified oligodeoxynucleotides on a reverse-phase polystyrene (PRP-1) column”, download from www.ncbi.nlm.nih.gov, Sep. 9, 2003.
Article by Bosch, JT, et al., entitled “Validation of Sequence-Optimized 70 Base Oligonucleotides for Use on DNA Microarrays”, pulished Sep. 2003, OPERON, A Qiagen Company.
Article by Kane, MD, et al., entitled “Assessment of the Sensitivity and Specificty of Oligonucleotide (50mer) Microarrays”, published in Nucleic Acids Research, 2000, vol. 28, No. 22, pp. 4552-4557.
Article by Huber, CG, et al., entitled “High-Resolution Liquid Chromatography of Oligonucleotides on Nonporous Alkylated Styrene-Divinylbenzene Copolymers”, published by Analytical Biochemistry, 212, pp. 351-358 (1993).
Article by Tallarico, JA., et al. entitled “An Alkylsilyl-Tethered, High-Capacity Solid Support Amenable to Divseristy-Oriented Synthesis for One-Bead,m One-Stock Solution Chemical Genetics”, published by Journal of Combinatorial Chemistry, 2001, vol. 3, No. 3, pp. 312-318.
Article by Tan, DS., et al., entitled Stereoselective Synthesis of over Two Million Compounds Having Structural Features Both Reminiscent of Natural Products and Compatible with Miniaturized Cell-Based Assays, published in J. Am. Chem. Soc, 1998, 120, pp. 8565-8566.
Abstract by Stirchak, EP entitled Uncharged stereoregular nucleic acid analogs: 2. Morpholion nucleoside oligomers with carbamate internucleoside linkages, published in Nucleic Acids Res. 1989, Aug. 11;17(15):6129-41.
Article by Beaucage, SL and Iyer, RP, entitled The Synthesis of Specific Ribonucleotides and Unrelated Phosphorylated Biomolecules by the Phosphoramidite Method, published in Tetrahedron, vol. 49, No. 46, pp. 10441-10488, 1993.
Article by Mertes, MP and Coats, EA entitled “Synthesis of Carbonate Analogs Dinucleosides”, published J. Med. Chem., 1969, vol. 12, pp. 154-157.
Article by Vasseur, et al., entitled “Oligonucleosides: Synthesis of a Novel Methylhydroxylamine-Linked Nucleoside Dimer and Its Incorporation into Antisense Sequences” published by J. Am. Chem. Soc, 1992, 114, pp. 4006-4007.
Article by Sood, A, et al., entitled “Boron-Containing Nucleic Acids” published by J. Am. Chem. Soc., 1990, 112, pp. 9000-9001.
Article by Musicki B and Widlanski TS entitled “Synthesis of Carbohydrate Sulfonates and Sulfonate Exters” published by J. Org. Chem., vol. 55, No. 14, 1990, pp. 4231-4233.
Article by Stirchak, EP and Summerton, JE entitled “Uncharged Stereoregular Nucleic Acid Analogues” published J. Org. Chem., 1987, 52, pp. 4202-4206.
Article by Reynolds, RC et al., entitled “Synthesis of Thymidine Dimers Containing Internucleoside Sulfonate and Sulfonamide Linkages” published by J. Org. Chem., 1992, 57, pp. 2983-2985.
Article by Samukov, VV et al., entitled 2-(4-Nitrophenyl)sulfonylethoxycarbonyl (Nsc) Group as a Base-Labile a-Amino Protection for Solid Phase Peptide Synthesis, published by Tetrahedron Letters, vol. 35, No. 42, pp. 7821-7824, 1994.
Article by Wang H. and Weller DD entitled “Solid Phase Synthesis of Neutral Oligonucleotide Analogues” published by Tetrahedron Letters, vol. 32, No. 50, pp. 7385-7388, 1991.
Article by Mungall, WS and Kaiser, JK entitled “Carbamate Analogues of Oligonucleotides” published by J. Org.Chem., vol. 42, No. 4, 1977, pp. 703-706.
Article by Coull, JM et al., entitled “Synthesis and Characterization of a Carbamate-Linked Oligonucleosides” published by Tetrahedron Letters, vol. 28, No. 7, pp. 745-748, 1987.
Article by Beaucage, SL and Iyer, RP, entitled “Advances in the Synthesis of Oligonucleotides by the Phosphoramidite Approach”, published by Tetrahedron , vol. 48, No. 12, pp. 2223-2311, 1992.
Article by Beaucage, SL and Iyer, RP, entitled “The Functionalization of Oligonucleotides Via Phosphoramidite Derivatives”, published by Tetrahedron , vol. 49, No. 10, pp. 1925-1963, 1993.

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