Organic compounds -- part of the class 532-570 series – Organic compounds – Radioactive metal containing
Patent
1987-06-24
1991-02-19
Maples, John S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Radioactive metal containing
424 11, C07F 1500
Patent
active
049945602
ABSTRACT:
A group of functionalized polyamine chelants that form complexes with radioactive rhodium are disclosed. The rhodium complexes can be attached to an antibody or antibody fragment and used for therapeutic or diagnostic purposes.
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Journal of Molecular Catalysis, 32 149-158, (1985), E. R. Savinova et al.,; "Catalysts for Dihydrogen Evolution from Water Based on Rhodium Complexes with Polyamines", part I. Structure of Phodium (III)-Polyamine Complexes.
Journal of Molecular Catalysis, 32 159-175, (1985), E. R. Savinova et al.; "Catalysts for Dihydrogen Evolution from Water Based on Rhodium-Polyamine Complexes Part II: The Activity of Catalysts and Nature of Their Active Components".
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D. E. Troutner and E. O. Schlemper, "Bifunctional Chelates of Rh-105 and Au-199 as Potential Radiotherapeutic Agents", Dept. of Energy Performance Report DOE/DE-FG02 86ER60400, Sep. 30, 1986.
T. Lynde-Kernell "Synthesis and Structural Studies of Rhodium(III) Complexes of Nitrogen Donor Ligands", Master Thesis, The Curators of the University of Missouri at Columbia, Dec. 1986.
Chen, Feng-Ming, "Metal Complexes of Tetradentate Nitrogen Ligands as Bifunctional Chelates for Radiolabling of Proteins", Ph.D. Thesis, The Curators of the University of Missouri at Columbia, 1985.
Fazio Michael J.
Fordyce William A.
Inbasekaran Muthiah N.
Kruper, Jr. William J.
Pollock Douglas K.
Maples John S.
The Dow Chemical Company
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