Functionalized polyamine chelants

Details Functionalized polyamine chelants Functionalized polyamine chelants

1993-03-15

1996-02-06

Wu, Shean

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

540474, 564305, 564463, A61K 5100, C07D25702, C07C21100

Patent

active

054894255

ABSTRACT:
A group of functionalized polyamine chelants that form complexes with rhodium are disclosed. The rhodium complexes can be attached to an antibody or antibody fragment and used for therapeutic or diagnostic purposes.

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I. Tabushi et al., Tetrahedron Letters, 12, 1049-1052 (1977).
D. E. Troutner et al., "Bifunctional Chelates Of Rh-105 And Au-199 As Potential Radiontherapeutic Agents", Dept. of Energy Performance Report DOE/DE-FG02 86ER60400, Sep. 30, 1986.
T. Lynde-Kernell, "Synthesis And Structural Studies Of Rhodium(III) Complexes Of Nitrogen Donor Ligands", Mater Thesis, Dec. 1986.
Feng-Ming Chen, "Metal Complexes Of Tetradentate Nitrogen Ligands As Bifunctional Chelates For Radiolabeling Of Proteins" Ph.D. Thesis, 1985.
Journal of Molecular Catalysis, 32, 149-158 (1985) E. R. Savinova et al., Part I.
Journal of Molecular Catalysis, 32, 149-158 (1985) E. R. Savinova et al., Part II.

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