Functionalized peptidylaminoalcohols

Details Functionalized peptidylaminoalcohols Functionalized peptidylaminoalcohols

1986-02-18

1988-02-16

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530331, 530332, A61K 3743, C07K 506, C07K 508

Patent

active

047255838

ABSTRACT:
The invention relates to renin inhibiting compounds of the formula ##STR1## wherein A is an N-protecting group; R.sub.1, R.sub.2 and R.sub.3 are independently selected from loweralkyl or lipophilic or aromatic amino acid side chains; and R.sub.4 is --CHO, --CO.sub.2 H, halomethyl or alkanoyl; and R.sub.5 is hydrogen or loweralkyl.

REFERENCES:
patent: 4474764 (1984-10-01), Umezawa et al.
patent: 4548926 (1985-10-01), Matsueda et al.
Biochem. and Biophys. Res. Commun., 118, No. 3 (1984), 929-933.
Chem. Abstr., vol. 100 (1984), 187896.
Chem. Abstr., vol. 99 (1983), 122938.
Chem. Abstr., vol. 78 (1973), 119129.
Chem. Abstr., vol. 79 (1973), 66807.
Chem. Abstr., vol. 93 (1980), 205010.
Chem. Abstr., vol. 100 (1984), 151619.
Chem. Abstr., vol. 102 (1985), 91909.

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