Functionalized macrocyclic ligands for imaging applications

Details Functionalized macrocyclic ligands for imaging applications Functionalized macrocyclic ligands for imaging applications

1994-01-14

1996-09-10

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540450, 540452, 540470, 534 10, 534 14, 534 15, 424 93, C07D25502, C07F 500

Patent

active

055547494

ABSTRACT:
The present invention provides new and structurally diverse compositions comprising compounds of the general formula: ##STR1## Wherein U is --(CH.sub.2).sub.n X or --(CH.sub.2).sub.n NR.sub.1 (CH.sub.2)X; R.sub.1 is hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 hydroxyalkyl or C.sub.1 -C.sub.8 alkoxyalkyl; V is --(CH.sub.2).sub.n X, --(CH.sub.2).sub.n NR.sub.1 (CH.sub.2)X, hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 hydroxyalkyl or C.sub.1 -C.sub.8 alkoxyalkyl; V and R.sub.1 may jointly be --(CH.sub.2).sub.m -- to form a heterocyclic ring; X is --CO.sub.2 H, --PO.sub.3 H.sub.2, --SO.sub.3 H or --CONHOH; a, b, c, d, n and m may be the same or different and are from one to about ten, preferably from one to about three.
Methods for imaging using compositions of the invention are also provided.

REFERENCES:
patent: 5247075 (1993-09-01), Parker et al.
patent: 5284944 (1994-02-01), Madison et al.
patent: 5342606 (1994-08-01), Sherry et al.

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