Functionalized intermediate for the synthesis of alpha-functiona

Details Functionalized intermediate for the synthesis of alpha-functiona Functionalized intermediate for the synthesis of alpha-functiona

1986-09-25

1989-01-03

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

562561, C07C 8720, C07C10124

Patent

active

047958286

ABSTRACT:
Procainamide and N-acetylprocainamide (NAPA) immunogens, antibodies prepared therefrom, labeled conjugates, synthetic intermediates, and the use of such antibodies and labeled conjugates in immunoassays for determining the respective drugs. The immunogens comprise the drugs coupled at the .alpha.-position of the amide side chain to an immunogenic carrier material. The labeled conjugates and synthetic intermediates similarly are .alpha.-position derivatives of the drugs or precursors thereof. The antibodies and labeled conjugates are particularly useful in homogeneous nonradioisotopic immunoassays for measuring the respective drugs in biological fluids such as serum.

REFERENCES:
patent: 3031490 (1962-04-01), Ferris et al.
patent: 4235969 (1980-11-01), Singh et al.

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