Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Diagnostic or test agent produces in vivo fluorescence
Reexamination Certificate
2007-07-17
2007-07-17
Zemel, Irina S (Department: 1711)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Diagnostic or test agent produces in vivo fluorescence
C428S402240, C428S403000, C428S404000, C427S213300, C427S215000, C427S220000, C424S009320, C424S009321, C424S009360
Reexamination Certificate
active
11301050
ABSTRACT:
Provided are a functionalized, encapsulated fluorescent nanocrystal comprising a liposome having encapsulated therein one or more fluorescent nanocrystals; use of the functionalized, encapsulated fluorescent nanocrystals in detection systems; and a method of producing functionalized, encapsulated fluorescent nanocrystals. A method of using the functionalized encapsulated fluorescent nanocrystals having affinity molecule bound thereto comprises contacting the functionalized encapsulated fluorescent nanocrystals with a sample so that complexes are formed between the functionalized encapsulated fluorescent nanocrystals and substrate for which the affinity molecule has binding specificity, if the substrate is present; exposing the complexes in the detection system to an excitation light source, and detecting a fluorescence peak emitted from the complexes, if present.
REFERENCES:
patent: 4614796 (1986-09-01), Kawamata et al.
patent: 5151507 (1992-09-01), Hobbs, Jr. et al.
patent: 5187085 (1993-02-01), Lee
patent: 5364759 (1994-11-01), Caskey et al.
patent: 5449556 (1995-09-01), Law et al.
patent: 5525377 (1996-06-01), Gallagher et al.
patent: 5558991 (1996-09-01), Trainor
patent: 5578718 (1996-11-01), Cook et al.
patent: 5637258 (1997-06-01), Goldburt et al.
patent: 5650277 (1997-07-01), Navot et al.
patent: 5679785 (1997-10-01), Engels et al.
patent: 5990479 (1999-11-01), Weiss et al.
patent: 6114038 (2000-09-01), Castro et al.
patent: 6179912 (2001-01-01), Barbera-Guillem et al.
patent: 6207392 (2001-03-01), Weiss et al.
patent: 6221602 (2001-04-01), Barbera-Guillem et al.
patent: 6761877 (2004-07-01), Barbera-Guillem
patent: WO 00/28089 (2000-05-01), None
Chan et al., Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection, 1998, Science 281:2016-2018.
Bruchez Jr. et al., Semiconductor Nanocrystals as Fluorescent Biological Labels, 1998, Science 281:2013-2015.
Kennedy et al., Cryo-Transmission Electron Microscopy Confirms Controlled Synthesis of Cadmium Sulfide Nanocrystals within Lecithin Vesicles, 1998, Chem. Mater. 10:2116-2119.
Korgel et al., Synthesis of Size-Monodisperse CdS Nanocrystals Using Phosphatidycholine Vesicles as True Reaction Compartments, 1996, J. Phys. Chem. 100:346-351.
Hui et al., The role of helper lipids in cationic liposome-mediated gene transfer, 1996, Biophysical J. 71(2):590-599.
Jacoby, Quantum Dots meet Biomolecules: Method uses brightly fluorescing semiconductor nanocrystals as labels, 1998, C & EN 76:8.
Invitrogen Corporation
Zemel Irina S
LandOfFree
Functionalized encapsulated fluorescent nanocrystals does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Functionalized encapsulated fluorescent nanocrystals, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Functionalized encapsulated fluorescent nanocrystals will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3733950