Functionalized aza-crytand ligands for diagnostic imaging applic

Details Functionalized aza-crytand ligands for diagnostic imaging applic Functionalized aza-crytand ligands for diagnostic imaging applic

1993-10-04

1995-05-23

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 165, 424 177, 424 942, 534 15, 534 16, 540465, 540472, 1286534, 514183, 514186, 514431, 514450, 436173, A61B 5055, C07D22500, C07D24500

Patent

active

054179599

ABSTRACT:
The present invention provides new and structurally diverse compositions comprising compounds of the general formula: ##STR1## Wherein V is CR.sub.1 or N; W is CR.sub.2 or N; R.sub.1 and R.sub.2 may be the same or different and are hydrogen, C.sub.1 -C.sub.8 alkyl, or C.sub.6 -C.sub.10 aryl, optionally R.sub.1 and R.sub.2 may be substituted by one or more hydroxy, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 hydroxyalkyl, C.sub.1 -C.sub.8 alkoxy, C.sub.6 -C.sub.10 aryl, C.sub.6 -C.sub.10 hydroxyaryl, C.sub.6 -C.sub.10 aryloxy, --CO.sub.2 R.sub.3, CONR.sub.4 R.sub.5, or --NR.sub.4 R.sub.5 ; X and Y may be the same or different and the O, NR.sub.6, S, or CR.sub.7 R.sub.8 ; R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 may be the same or different and are hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 hydroxyalkyl, or C.sub.1 -C.sub.8 alkoxyalkyl; R.sub.4 and R.sub.5 may form a 5 or 6 membered carbocyclic ring optionally containing singularly or in combination nitrogen, oxygen or sulfur; a, b, c, d and e may be same or different and are zero to about 10; and Z is --CO.sub.2 H, --PO.sub.3 H.sub.2, --SO.sub.3 H, or --CONHOH.
Methods for imaging using compositions of the invention as diagnostic imaging agents are also provided.

REFERENCES:
patent: 3531468 (1970-09-01), Park et al.
patent: 4927923 (1990-05-01), Mathis et al.
patent: 5322681 (1994-06-01), Klaveness

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