Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Reexamination Certificate
2003-10-01
2010-12-14
Crow, Robert T. (Department: 1634)
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
C435S006120, C435S287100, C204S403060, C205S778000
Reexamination Certificate
active
07851203
ABSTRACT:
Disclosed are nanometer to micron scale functionalized apertures constructed on a substrate made of glass, carbon, semiconductors or polymeric materials that allow for the real time detection of biological materials or chemical moieties. Many apertures can exist on one substrate allowing for the simultaneous detection of numerous chemical and biological molecules. One embodiment features a macrocyclic ring attached to cross-linkers, wherein the macrocyclic ring has a biological or chemical probe extending through the aperture. Another embodiment achieves functionalization by attaching chemical or biological anchors directly to the walls of the apertures via cross-linkers.
REFERENCES:
patent: 5104820 (1992-04-01), Go et al.
patent: 5843767 (1998-12-01), Beattie
patent: 2002/0191884 (2002-12-01), Letant et al.
patent: WO 00/79257 (2000-12-01), None
Akeson et al, Biophys. J., vol. 77, pp. 3227-3233 (1999).
Hoger, J. Polymer Sci. Part A: Poly. Chem., vol. 37, pp. 2685-2698 (1999).
Letant et al (Nature Materials, vol. 2, pp. 391-395 (Jun. 2003).
Stryer, Biochemistry, 2nd ed., pp. 13-15 and 575 (1981).
Stryer, Biochemistry, 2nd ed, W.H.Freeman and Co., New York, pp. 17 and 576 (1981).
Hart Bradley R.
Hope-Weeks Louisa J.
Letant Sonia E.
Terminello Louis J.
Thelen Michael P.
Crow Robert T.
Lawrence Livermore National Security LLC
Lee John H.
Tak James S.
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