Functional recombinantly prepared synthetic protein polymer

Details Functional recombinantly prepared synthetic protein polymer Functional recombinantly prepared synthetic protein polymer

1990-11-06

1996-05-07

Fleisher, Mindy

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

43525233, 4353201, 536 234, C12N 121, C12N 1570, C12N 1512

Patent

active

055145817

ABSTRACT:
Novel polymers are provided which are produced by recombinant techniques. The polymers are characterized by having a small repeating sequence which provides for strands capable of associating, resulting in useful structural characteristics, where the strands are joined by turns or loops which are flexible and available for interaction with the environment. Specifically, repeating groups of naturally occurring proteins such as silk are modified by introduction of an amino-acid sequence at a site which provides for a turn between strands to provide for readily available oligopeptides capable of interacting with molecules in the environment.

REFERENCES:
patent: 4614517 (1986-09-01), Ruoslahti et al.
patent: 5243038 (1993-09-01), Ferrari et al.
Brack et al., Biopolymers, vol. 11, 1972, pp. 563-586.
Doel et al., Nuc. Acids Res., vol. 8, 1980, pp. 4574-4592.
Dixon, Bio/Technology, vol. 3, 1985, p. 67.

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