Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1982-04-02
1984-01-10
Rosen, Sam
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
424101, A61K 3700, A61K 3514
Patent
active
044253346
ABSTRACT:
Functional oxygen transport systems (OTS) have been devised which may serve as temporary blood substitutes in the circulatory system. The OTS comprises pure crystalline hemoglobin dissolved in an aqueous solution and encapsulated within a complex lipid and carbohydrate modified lipid phase. The hemoglobin encapsulated inner aqueous phase and the encapsulating lipid phase are dispensed in an outer isotonic aqueous phase to form a suspension of the multiple water-in-oil-in water emulsion type. The emulsion is suitable to transfusion into the circulatory system to assist in oxygen transport. The carbohydrate modified lipids are included in the lipid phase to "mask" the OTS from the tissue binding and take up by the reticuloendothelial system. The OTS are also suitable for use as calibrating fluids in gas analysis apparatus.
REFERENCES:
patent: 3887698 (1975-06-01), McConnell et al.
patent: 4001401 (1977-01-01), Bonsen et al.
patent: 4061736 (1977-12-01), Morris et al.
patent: 4078052 (1978-03-01), Papahadjopoulos et al.
patent: 4089801 (1978-05-01), Schneider
patent: 4133874 (1979-01-01), Miller et al.
patent: 4186183 (1980-01-01), Steck et al.
patent: 4192869 (1980-03-01), Nicolau et al.
patent: 4193983 (1980-03-01), Ullman et al.
patent: 4217344 (1980-08-01), Vanlerberghe et al.
patent: 4224179 (1980-09-01), Schneider
patent: 4229360 (1980-10-01), Schneider et al.
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4241046 (1980-12-01), Papahadjopoulos et al.
patent: 4247411 (1981-01-01), Vanlerberghe et al.
Djordjevich, L., et al., Experimental Hematology, vol. 8, pp. 584-592 (1980), "Synthetic Erythrocytes from Lipid Encapsulated Hemoglobin".
Gregoriadis, G., FEBS Letters, vol. 36, pp. 292-296 (1973), "Drug Entrapment in Liposomes".
Koazo, F., et al., Brochimica et Biophysica Acta, vol. 363, pp. 182-189 (1974), "Liposome Model Experiment for the Study of Assumed Membrane Damage in Porphyria Cutanea Tarda".
Calissano, F., et al., Biochemical and Biophysical Research Communications, vol. 43, pp. 504-509 (1971), "Effect of Two Brain Specific Proteins on Cation Diffusion Across Artificial Lepid Membranes."
Shubert, D., et al., Chemical Abstracts, vol. 79, 107 Item 1228115 (1973), "Formation and Properties of Lipoprotein Membranes from Proteins and Lipids of the Human Erythrolyte Membrane".
Nichols, P., et al., Biochimica et Biophysica Acta, vol. 363 (1974), "Chlorophyll b Containing Liposomes: Effects of Thermal Transitions on Catalytic and Spectral Properties".
Papahadjopoulos, D., et al., Biochimica et Biophysica Acta, vol. 363, pp. 404-418 (1974), "Cellular Uptake of Cyclic AMP Captured Within Phospholipid Vesicles and Effect on Cell-Growth Behaviour".
Rosen Sam
The Regents of the University of California
LandOfFree
Functional oxygen transport system does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Functional oxygen transport system, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Functional oxygen transport system will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-453291