Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
2006-08-22
2006-08-22
Casler, Brian L. (Department: 3737)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
C600S407000, C600S408000, C600S423000, C324S306000, C324S309000, C324S318000, C324S322000
Reexamination Certificate
active
07096056
ABSTRACT:
A method for functional magnetic resonance imaging (fMRI) uses steady-state free precession (SSFP) to image changes in blood oxygenation between two time periods. A center frequency of the SSFP sequence is placed between the different resonant frequencies for oxyhemoglobin and deoxyhemoglobin whereby the signals have a phase difference of 180° and tend to cancel. By repeating the SSFP imaging sequence at different times, the difference in the measured signals provides a measure of change in oxyhemoglobin. RF flip angle of the SSFP sequence is chosen to maximize signal level in the frequency range from that of water in the presence of oxyhemoglobin and that of water in the presence of deoxyhemoglobin.
REFERENCES:
patent: 6271665 (2001-08-01), Berr et al.
patent: 6307368 (2001-10-01), Vasanawala et al.
patent: 6400978 (2002-06-01), Teicher et al.
patent: 2004/0092809 (2004-05-01), DeCharms
Scheffler and Hennig, “Is TrueFISP a Gradient-Echo or a Spin-Echo Sequence?” Magnetic Resonance in Medicine 49:395-397 (2003).
Scheffler et al., “Detection of BOLD changes by means of a frequency-sensitive true FISP technique: preliminary results,” NMR in Biomedicine 14:490-496 (2001).
Ogawa et al., “Brain magnetic resonance imaging with contrast dependent on blood oxygenation,” Proc. Natl. Acad. Sci., USA, vol. 87, pp. 9868-9872, Dec. 1990.
Ogawa et al., “Instrinsic signal changes accompanying sensory stimulation: Functional brain mapping with magnetic resonance imaging,” Proc. Natl. Acad. Sci., USA, vol. 89, pp. 5951-5955, Jul. 1992.
Kwong et al., “Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation,” Proc. Natl. Acad. Sci., USA, vol. 89, pp. 5675-5679, Jun. 1992.
Miller Karla L.
Pauly John M.
Beyer Weaver & Thomas LLP
Casler Brian L.
Ramirez John F.
The Board of Trustees of the Leland Stanford Junior University
LandOfFree
Functional magnetic resonance imaging using steady state... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Functional magnetic resonance imaging using steady state..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Functional magnetic resonance imaging using steady state... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3692452