Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Patent
1995-11-13
1999-01-12
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
435375, 435334, 435355, 435372, 435 71, C12N 500
Patent
active
058587829
ABSTRACT:
The present invention provides compositions of purified cells that are selectively enriched for proliferating hematopoietic progenitor cells. These cells are both CD34 positive and express a galactose-binding surface structure. Methods for the purification and use of these cells, for example, in improving transplantations and reducing graft-versus-host disease also are provided.
REFERENCES:
patent: 4965204 (1990-10-01), Civin
patent: 5130144 (1992-07-01), Civin
patent: 5486359 (1996-01-01), Caplan et al.
Craig et al., "Use of Lectins for Characterization and Purification of Human Bone Marrow Cells that Express CD34," J Hematotherapy, 1:55-64, 1992.
Morstyn et al., "Purification of Hemopoietic Progenitor Cells from Human Marrow Using a Fucose Binding Lectin and Cell Sorting," Blood, 56:798-805, 1980.
van der Valk et al., "Immunohistochemistry in Bone Marrow Diagnosis Value of a Panel of Monoclonal Antibodies on Routinely Processed Bone Marrow Biopsies," Am J Surgical Pathology, 13(2):97-106, 1989.
Pipiya, et al., "Functional Assessment of Hematopoietic Lectin Expression on CD34.sup.+ Cells", Blood, vol. 84, No. 10 (Suppl. 1), p. 575A, (1994) Abstract No. 2284.
Pipiya, et al., "Functional Human Hematopoietic Cells Express Galactose-Binding Cell Surface Lectins", Blood, vol. 86, No. 10 (Suppl. 1), p. 307A, (1995) Abstract No. 1215.
International Search Report for PCT US 96/18170, Nov. 13, 1996.
Long Michael W.
Pipia George G.
Chambers Jasemine C.
Hauda Karen M.
Regents of the University of Michigan
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