Functional DNA block and plasmid coding for hirudin, transformed

Details Functional DNA block and plasmid coding for hirudin, transformed Functional DNA block and plasmid coding for hirudin, transformed

1995-03-16

1997-01-07

Wax, Robert A.

Chemistry: molecular biology and microbiology

Vector, per se

536 2351, 536 241, 536 242, 530300, C12N 1564, C12N 1552, C07H 1700, C07K 14815

Patent

active

055916406

ABSTRACT:
The invention relates to a functional DNA block by means of which hirudin may be prepared from yeast, which block contains at least the sequence:

REFERENCES:
patent: 4356270 (1982-10-01), Itakura
patent: 4546082 (1985-10-01), Kurjan
patent: 4769326 (1988-09-01), Rutter
Proceedings of the National Academy of Sciences of the USA 83 (1986) Febr., No. 4, Washington, USA; Cloning and Expression of a cDNA Coding for the Anticoagulant Hirudin from the Bloodsucking Leech, Hirudo Medicinalis; Harvey et al.
Woods et al. J. Clin. Invest. vol. 74 pp. 634-638 (1984).
Molecular Biology of the Gene 3rd Edition W. A. Benjamin, Inc. p. 356 (1976).
Pouwrels et al eds in Cloning Vectors VIBi5 VI-3 VI-4.
Dodt et al (1984) FEBS Lett 165: 180-183.
Achstetter et al (1985) EMBO J 4:173-177.
Bitter et al (1984) PNAS 81:5330-5334.
Brake et al (1984) PNAS 81:4642-4646.
Suggs et al (1981) PNAS 78:6613-6617.

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