Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2003-07-25
2009-11-03
Bertoglio, Valarie (Department: 1632)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S366000, C435S375000, C435S377000
Reexamination Certificate
active
07611852
ABSTRACT:
Human embryonic stem cells form embryoid bodies in culture which contain differentiated human cells. Some of the human cells in embryoid bodies differentiate into cardiomyocytes. Here the biological and electrical characteristics of those cardiomyocytes are described with reference to the use of cardiomyocytes derived from human embryonic stem cells in drug screening protocols for mechanisms of cardiac toxicity.
REFERENCES:
patent: 5928943 (1999-07-01), Franz et al.
patent: 2002/0092035 (2002-07-01), Hescheler
patent: 2003/0232431 (2003-12-01), Law
patent: 2005/0037489 (2005-02-01), Gepstein et al.
patent: 198 43 234 (2000-03-01), None
patent: 198 43 234 (2003-03-01), None
U.S. Appl. No. 60/306,462.
Bosch et a. Effects of the chromanol 293B, a selective blocker of the slow, component ofthe delayed rectifier K+ current, on repolarization in human and guinea pig ventricular myocytes.Cardiovasc Res. May 1998;38(2):441-50.
Carlsson et al. Electrophysiological characterization of the prokinetic agents cisapride and mosapride in vivo and in vitro: implications for proarrhythmic potential?J Pharmacol Exp Ther. Jul. 1997;282(1):220-7.
Li et al. Evidence for two components of delayed rectifier K+ current in human ventricular myocytes. Circ Res. Apr. 1996;78(4):689-96.
Priori et al. (1996) Circ. Res. 78:1009-1015.
Bauwens, CI et al, 2008, Control of human embryonic stem cell colony and aggregate size heterogeneity influences differentiation trajectories, Stem Cells, 26:2300-2310.
Burridge, PW et al, 2007, Improved human embryonic stem cell embryoid body homogeneity and cardiomyocyte differentiation from a novel V-96 plate aggregation system highlights interline variability, 25:929-938.
Gryshchenko, O., et al., “Role of ATP-dependent K+ channels in the electrical excitability of early embryonic stem . . . ,” Journal of Cell Science 112:2903-2912 (1999).
He, J-Q, et al., “Human Embryonic Stem Cells Develop into Multiple Types of Cardiac Myocytes: Action Potential Characterization,” Circ. Res. 93:32-39 (2003).
Kolossov, E., et al., “Functional Characteristics of ES Cell-derived Cardiac Precursor Cells Identified by Tissue-specific Expression . . . ,” J. of Cell Biol. 143:2045-2056 (1998).
Maltsev, V.A., et al., “Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial . . . ,” Mechanisms of Development 44:41-50 (1993).
Maltsev, V.A., et al., Cardiomyocytes Differentiated In Vitro From Embryonic Stem Cells Developmentally Express . . . , Circulation Research 75:233-244 (1994).
Maltsev, V.A., et al., “Establishment of beta-Adrenergic Modulation of L-Type Ca2+ Current in the Early Stages . . . ,” Circulation Research 84:136-145 (1999).
He Jia-Qiang
Kamp Timothy J.
Ma Yue
Thomson James A.
Bertoglio Valarie
Quarles & Brady LLP
Wisconsin Alumni Research Foundation
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