Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus esters
Reexamination Certificate
2004-09-08
2010-06-08
Jiang, Shaojia Anna (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Phosphorus esters
Reexamination Certificate
active
07732628
ABSTRACT:
Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
REFERENCES:
patent: 3939123 (1976-02-01), Matthews et al.
patent: 4006117 (1977-02-01), Merrifield
patent: 4162355 (1979-07-01), Tsibris
patent: 4171412 (1979-10-01), Coupek et al.
patent: 4175183 (1979-11-01), Ayers
patent: 4177038 (1979-12-01), Biebricher et al.
patent: 4178439 (1979-12-01), Ayers et al.
patent: 4180524 (1979-12-01), Reusser et al.
patent: 4241537 (1980-12-01), Wood
patent: 4337063 (1982-06-01), Mihara et al.
patent: 4404289 (1983-09-01), Masuda et al.
patent: 4405711 (1983-09-01), Masuda et al.
patent: 4439585 (1984-03-01), Gould et al.
patent: 4485227 (1984-11-01), Fox
patent: 4507230 (1985-03-01), Tam et al.
patent: 4569981 (1986-02-01), Wenzel et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4707440 (1987-11-01), Stavrianopoulos
patent: 4833251 (1989-05-01), Musso et al.
patent: 4874813 (1989-10-01), O'Shannessy
patent: 4889798 (1989-12-01), Rabbani
patent: 4927879 (1990-05-01), Pidgeon
patent: 4931498 (1990-06-01), Pidgeon
patent: 5092992 (1992-03-01), Crane et al.
patent: 5130446 (1992-07-01), Musso et al.
patent: 5151507 (1992-09-01), Hobbs, Jr. et al.
patent: 5206370 (1993-04-01), Schwartz et al.
patent: 5210203 (1993-05-01), Musso et al.
patent: 5237016 (1993-08-01), Ghosh et al.
patent: 5242756 (1993-09-01), Hensel et al.
patent: 5242796 (1993-09-01), Prober et al.
patent: 5328603 (1994-07-01), Velander et al.
patent: 5334640 (1994-08-01), Desai et al.
patent: 5389449 (1995-02-01), Afeyan et al.
patent: 5403750 (1995-04-01), Braatz et al.
patent: 5420285 (1995-05-01), Schwartz et al.
patent: 5432018 (1995-07-01), Dower et al.
patent: 5474895 (1995-12-01), Ishii et al.
patent: 5478893 (1995-12-01), Ghosh et al.
patent: 5486616 (1996-01-01), Waggoner et al.
patent: 5521290 (1996-05-01), Sivam et al.
patent: 5547835 (1996-08-01), Koster
patent: 5547839 (1996-08-01), Dower et al.
patent: 5556752 (1996-09-01), Lockhart et al.
patent: 5569587 (1996-10-01), Waggoner
patent: 5569766 (1996-10-01), Waggoner et al.
patent: 5627027 (1997-05-01), Waggoner
patent: 5663242 (1997-09-01), Ghosh et al.
patent: 5679778 (1997-10-01), Abrams et al.
patent: 5726329 (1998-03-01), Jones et al.
patent: 5741462 (1998-04-01), Nova et al.
patent: 5744305 (1998-04-01), Fodor et al.
patent: 5751629 (1998-05-01), Nova et al.
patent: 5753520 (1998-05-01), Schwartz et al.
patent: 5789576 (1998-08-01), Daily et al.
patent: 5792615 (1998-08-01), Arnold et al.
patent: 5824473 (1998-10-01), Meade et al.
patent: 5837856 (1998-11-01), Arnold, Jr. et al.
patent: 5837860 (1998-11-01), Anderson et al.
patent: 5854410 (1998-12-01), Arnold, Jr. et al.
patent: 5856571 (1999-01-01), Berninger et al.
patent: 5874214 (1999-02-01), Nova et al.
patent: 5874552 (1999-02-01), Jones et al.
patent: 5876938 (1999-03-01), Stolowitz et al.
patent: 5877220 (1999-03-01), Schwartz et al.
patent: 5880270 (1999-03-01), Berninger et al.
patent: 5925562 (1999-07-01), Nova et al.
patent: 5952172 (1999-09-01), Meade et al.
patent: 5955597 (1999-09-01), Arnold, Jr. et al.
patent: 5958901 (1999-09-01), Dwyer et al.
patent: 5961923 (1999-10-01), Nova et al.
patent: 5972639 (1999-10-01), Parandoosh
patent: 6001826 (1999-12-01), Murrer et al.
patent: 6017496 (2000-01-01), Nova et al.
patent: 6020526 (2000-02-01), Schwartz et al.
patent: 6025129 (2000-02-01), Nova et al.
patent: 6028188 (2000-02-01), Arnold, Jr. et al.
patent: 6034135 (2000-03-01), Schwartz et al.
patent: 6066448 (2000-05-01), Wohlstadter et al.
patent: 6071699 (2000-06-01), Meade et al.
patent: 6074823 (2000-06-01), Koster
patent: 6087186 (2000-07-01), Cargill et al.
patent: 6217845 (2001-04-01), Schwartz et al.
patent: 0361768 (1989-09-01), None
patent: 0384769 (1990-02-01), None
patent: 0384769 (1990-02-01), None
patent: 0772135 (1996-06-01), None
patent: 9815825 (1998-04-01), None
patent: 9831732 (1998-07-01), None
patent: 9965993 (1999-12-01), None
patent: 0004382 (2000-01-01), None
patent: 0004389 (2000-01-01), None
patent: 0004390 (2000-01-01), None
patent: 0008042 (2000-02-01), None
patent: 0040590 (2000-07-01), None
patent: 0040590 (2000-07-01), None
patent: 0109385 (2001-02-01), None
Tsou et al. Journal of Medicinal Chemistry, 1967, 10(4), p. 662-664.
Garrett et al. Biochemistry, 1999, Saunders College Publishing, 2nd edition, p. 382-384.
Horwitz et al. J. Med. Chem. 1970, 13(5), p. 1024-1025.
Bologna et al. Eur. J. Org. Chem. 1999, p. 2353-2358.
Patani et al. Chem. Rev, 1996, 96, p. 3147-3176.
“IUPAC-IUB Commission on Biochemical Nomenclature, Abbreviated Nomenclature of Synthetic Polypeptides (Polymerized Amino Acids), Revised Recommendations (1971),”Biochem. 11(5): 942-4 (1972).
Abrams et al. “Technetium-99m-Human Polyclonal IgG Radiolabeled via the Hydrazino Nicotinamide Derivative for Imaging Focal Sites of Infection in Rats,”J. Nucl. Med. 31:2022-8 (1990).
Adleman et al. “Molecular Computation of Solutions to Combinatorial Problems,”Science266: 1021-4 (1994).
Agrawal, S. “Importance of nucleotide sequence and chemical modifications of antisense oligonucleotides,”Biochim. Biophys. Acta. 1489: 53-68 (1999).
Agrawal, S. (Ed.) “Protocols for Oligonucleotides and Analogs,”Methods in Molecular Biology20 (Humana Press, 1993).
Berg et al. “Polystyrene-Grafted Polyethylene: Design of Film and felt Matrices for Solid-Phase Peptide Synthesis,”Innovation Perspect Solid Phase Synth. Collect. Pap., Int. Symp., 1st, Epton R. (Ed.) pp. 453-459 (1989).
Berg et al. “Long-Chain Polystyrene-Grafted Polyethylene Film Matrix: A New Support for Solid-Phase Peptide Synthesis,”J. Am. Chem. Soc. 111: 8024-6 (1989).
Berg et al. “Peptide Synthesis on Polystyrene-Grafted Polyethylene Sheets,”Pept. Proc. Eur. Pept. Symp., 20th, Jung, G. et al. (Eds.) pp. 196-198 (1989).
Bielinska et al. “Application of membrane-based dendrimer/DNA complexes for solid phase transfection in vitro and in vivo,”J. Biomaterials21: 877-887 (2000).
Blomqvist et al. “Rapid Detection of Human Rhinoviruses in Nasopharyngeal Aspirates by a Microwell Reserve Transcription-PCR-Hybridization Assay,”J. Clin. Microbiol. 37: 2813-6 (1999).
Brown, M.P. and Royer, C. “Fluorescence spectroscopy as a tool to investigate protein,”Curr. Opin. Biotechnol. 8: 45-9 (1997).
Browne, D.W. and Dyson, G.M. “The Inhibitory Effect of Substituents in Chemical Reactions. Part III. The Reactivity of theisoThiocyano-group in Substituted Arylthiocarbimides,”J. Chem. Soc. 178-9 (1934).
Carlsson, B. and Haggblad, J. “Quantitative Determination of DNA-Binding Parameters for the Human Estrogen Receptor in a Solid-Phase Nonseparation Assay,”Anal. Biochem. 232: 172-9 (1995).
Chen et al. “Stable-Isotope-Assisted MALDI-TOF Mass Spectrometry for Accurate Determination of Nucleotide Compositions of PCR Products,” 71: 3118-25 (1999).
Compagno et al. “Antisense Oligonucleotides Containing Modified Bases Inhibit in Vitro Translation ofLeishmania amazonensismRNAs by Invading the Mini-exon Hairpin,”J. Biol. Chem. 274: 8191-8 (1999).
Cristiano, R. J. and Roth, J.A. “Epidermal growth factor mediated DNA delivery into lung cancer cells via the epidermal growth factor receptor,”Cancer Gene Therapy3: 4-10 (1996).
Crooke, S.T. “Molecular mechanisms of action of antisense drugs,”Biochim. Biophys. Acta. 1489: 31-44 (1999).
De Benedetti et al. “DNA chips: the future of biomarkers,”Int. J. Biol. Markers15(1): 1-9 (2000).
Earnshaw et al. “Investigation of the Proposed Interdomain Ribose Zi
Hogrefe Richard I.
Schwartz David A.
Jiang Shaojia Anna
Lau Jonathan S
Solulink Incorporated
The Nath Law Group
Waller David B.
LandOfFree
Functional biopolymer modification reagents and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Functional biopolymer modification reagents and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Functional biopolymer modification reagents and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4244690