Functional assay of high-density lipoprotein

Details Functional assay of high-density lipoprotein Functional assay of high-density lipoprotein

2005-03-22

2005-03-22

Wallenhorst, Maureen M. (Department: 1743)

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Calorimeter

C422S051000, C436S063000, C436S071000, C436S169000, C436S170000

Reexamination Certificate

active

06869568

ABSTRACT:
This invention provides novel assays that are prognostic and/or diagnostic for atherosclerosis or risk of atherosclerosis. It was discovered that high density lipoprotein (HDL) or components thereof can prevent the oxidation of lipids (e.g. lipids present in LDLs) and can also repair (reduce) already oxidized lipids and thereby reduce the inflammatory response associated with and characteristic of atherosclerotic plaque formation. Moreover it was a discovery of this invention that individuals vary in the ability of their HDL to afford such protection. Thus an assay of HDL protective and/or repair activity provides a highly effective assay for risk of atherosclerosis and its associated pathologies and such assays are provided herein.

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